摘要
目的 评价急性心肌梗死（AMI）患者中性粒细胞（PMN）氧化代谢功能以及维生素C的抗氧化损伤作用。方法 共有60例AMI患者被列入研究对象，随机分成两组，Ⅰ组（30例）给予AMI的常规治疗，Ⅱ组（30例）在常规治疗的基础上加用维生素C静脉滴注，每天3g ,连续应用7d后停药，在入院后第1，3，7，10天检测中性粒细胞化学发光（PMN－CL）参数，并行心电图检查，62例与AMI患者年龄性别匹配的健康人作为对照组（Ⅲ组）。结果 AMI患者PMN－CL各项参数显著性高于健康对照组。在第3、7天，Ⅱ组PMN－CL的各项参数较Ⅰ组明显下降，在偏旁 用维生素C后3d仍较Ⅰ组明显下降（P分别＜0.05，0.01，0.001），心电图ST段改善的积分明显高于Ⅰ组。结论 AMI患者PMN产生大量的氧自由基（OFR），造成机体氧化损伤；静脉滴注维生素C能有效抑制AMI患者PMN产生OFR，从而能减轻AMI患者心肌的进一步坏死。
Objective\ To evaluate the role of polymorphonuclear (PMN) in patients with acute myocardial infarction (AMI).The preventive effects of Vitamin C-a potent free radical scavenger,on parameters of PMN oxygen free radicals (OFR) production in patients with AMI were also studied.Methods\ 60 patients with AMI were randomized to receive either conventional treatment only (group Ⅰ,n=30) or conventional treatment supplemented with vitamin C infusion, 3.0 g/d,for 7 days (group Ⅱ,n=30).Parameters of PMN OFR production were assayed by a method named as polymorphonuclear chemiluminescence (PMN-CL) on the 1st,3rd,7th and 10th day after been hospitalized.62 healthy controls of similar age,sex were also studied.Results\ Parameters of PMN-CL increased significantly in patients with AMI compared with that in the healthy controls.Parameters of PMN-CL decreased significantly in group Ⅱ on the 3rd,7th and 10th day compared with that in group Ⅰ(P<0.05,0.01,0.001,respectively).ST segment score was significantly higher in group Ⅱ than that in group Ⅰ on the 3rd,7th and 10th day.Conclusion\ These results indicate that the PMN act as a potential contributor to extension of tissue injury induced by OFR.Supplementation with vitamin C may suppress PMN OFR production and could be beneficial in preventing myocardial necrosis.
出处
《医师进修杂志》
北大核心
2001年第5期12-14,共3页
Journal of Postgraduates of Medicine
关键词
急性心肌梗死
维生素C
中性粒细胞
氧自由基
acute myocardial infarction
vitamin C
polymorphonuclear
oxygen free radical
