摘要
用激素荧光素结合物检测法对25例正常人体涎腺组织和70例涎腺肿瘤组织进行了雌激素受体(ER)和孕激素受体(PR)的检测。提出了观察涎腺及其肿瘤组织中 ER 和 PR 阳性、阴性反应细胞的判断标准。初步认为:人体涎腺组织中可能有雌激素或孕激素作用的靶细胞存在,即涎腺腺上皮细胞,且腮腺中数量为多。瘤组织(HR)阳性反应的程度与涎腺肿瘤的部位、病理类型和分化程度有一定关系。部份 HR 阳性反应细胞检出较多的腮腺肿瘤可能是属激素依赖性肿瘤。
In this study,choosing the cytohistochemical methods according to Lee's histoche-mical fluorescent conjugate techniquein the Hospital of Stomatology,WCUMS.The authorsinvestigated the estrogen and progesterone receptors in 25 cases of normal salivary tiss-ues and 70 cases of salivary tumors,They have drawn up a standard for judging thepositive or negative reaction in accordance to use in human mammary carcinoma.In the epithelial cells of the normal salivary gland,there were found both positiveand negative reaction of hormone receptors,but negative reaction was in the connectivetissue cells.The distribution of the HR positive cells was different in the duct system.Consequently,it may be considered that there might have estrogen-dependent“targetcell”in the human salivary glands,which seem to be the positive reaction epithelialcells.In the benign tumors of the salivary gland,there were found out with a lot ofpositive reactional tumor cells.In the maligaant tumors of the salivary glands,HR pos-itive cells were predominant in the parotie gland and its tumors.It seems to be somerelationship between the rate of positive reaction hormone receptor cells and pathologi-cal type and differentiation of the cells.It was considered that the tumors of parotidgland,which contained more ER or PR,may be the hormone-dependented tumors.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1991年第3期182-186,I009,共6页
West China Journal of Stomatology
