摘要
目的回顾性分析超长食管癌＞８ｃｍ不同治疗方法治疗后的疗效，探讨超长食管癌的治疗对策。材料与方法对１９８７年３月至１９９２年３月间１９４例超长食管癌单纯外放射治疗、外放射＋腔内放疗、单纯手术治疗、术后放疗和未治疗的患者的生存率采用Ｋａｐｌａｎ－Ｍｅｉｅｒ分析，Ｌｏｇ－ｒａｎｋ检验，其它结果采用χ２检验，探讨不同治疗方法的疗效及失败原因。结果超长食管癌术后放疗疗效最好，姑息术后放疗能明显提高５年生存率（Ｐ＜０．０５），根治术后放疗５年生存率比单纯手术提高１５．１％，术后放疗能明显降低淋巴结的转移率（Ｐ＜０．０５）。超长食管癌失败的主要原因为局部未控或复发和远处转移，外放射＋腔内放疗有降低局部未控或复发的趋势。结论对超长食管癌的治疗应采取积极的治疗措施，能够手术治疗的应尽可能地根治性切除，术后均应作放射治疗；不能手术治疗者应采用非常规分割外放射配合腔内放疗和全身化疗。
Purpose The treatment effects by radiotherapy alone,operation alone,postoperative radiotherapy and nontherapy for superlong esophageal carcinoma(>8cm) were retrospectively reviewed.Materials and Methods 194 patients with superlong esophageal carcinoma were treated by different therapy methods from 1987 to 1992.KaplanMeier survival analysis ,Logrank test and χ2 test were used to evaluate the treatment effects of different therapy methods and causes of failure.Results The 5year survival rates were markedly increased and lymph node metastasis rates were markedly decreased for patients with postoperative radiotherapy.Patients with external beam combined with intracavitary radiotherapy gave a better local control rates than those of external beam radiotherapy alone.Residual or recurrent cancer and metastasis were the main causes of failure.Conclusion Active therapy must be performed on superlong esophageal carcinoma.Postoperative radiotherapy must be carried out for operable superlong esophageal carcinoma.Nonconventional fractionation external beam combined with intracavitary radiotherapy and chemotherapy is the first choice for inoperable superlong esophageal carcinoma.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
1997年第4期221-224,共4页
Chinese Journal of Radiation Oncology
关键词
超长食管癌
外科手术
放射治疗
Superlong esophageal carcinoma Operation Radiotherapy
