摘要
本文结果表明β-胡萝卜素片剂或胶囊剂的药时曲线为一室模型;Tpeak分别为6.99±1.85和6.21±0.94d;Cmax分别为1.07±0.47和1.02±0.38mg/L;t_(1/2ke)分别为20.34±12.54和17.08±12.81d;AUC分别为18.51±6.33和16.13±4.48(mg/L)·d两种剂型间生物利用度参数无显著差异(p>0.05)。结果提示β-胡萝卜素片和胶囊具有相同的生物利用度。
Mutiple oral dose of 90mg β- Carotene tablet or capsule was given to 24 healthy male volunteersin a randomized study for 7 days. The β - carotene concentration in serum were determined and β - carotene bioavailabilies were studied. The results indicated that the serum concentration- time curves of the two preparations were fitted to one - compartment model. Tpeak of tablet and capsule were 6. 99 ± 1. 85 and 6. 21 ± 0. 94 days. Cmax 1.07±0.47 and 1.02± 0. 38 mg/L, Tl/2ke 20. 34± 12. 54 and 17.08±12.81 day, AUC 18.51±6.33 and 16. 13±4.48(mg/ L) · d-1 respectively. There was no significant difference in each pharmacokinelies parameters between the two preparations. The results suggested that the bioavailability of the two preparations was simillar.
出处
《儿科药学杂志》
CAS
1998年第1期12-16,共5页
Journal of Pediatric Pharmacy
