摘要
目的 分析后加速放射治疗食管癌的疗效。方法 自 1997年 8月至 1998年 4月对 73例经病理证实的食管鳞癌病人 ,随机分为两组 :常规组 (36例 )、后加速组 (37例 )。常规组照射 :180CGY/次 /日 ,5次 /周 ,总剂量为 6 6 .6GY/7.4周。后加速组照射 :前程为 180CGY/次 /日 ,5次 /周 ,剂量达 43 .2GY/4.6周 ,后改为 15 0CGY/次 ,2次 /日 ,间隔 6小时以上 ,10次 /周 ,总剂量为 6 7.2GY/6 .4周。结果 两组照射结束时 ,局控率无明显的差异 ,后加速组 1年生存率和局控率分别为 86 .5 % (32 /37)和 78.4% (2 9/37) ,常规组分别为 5 2 .8% (19/36 )和 5 0 % (18/36 ) ,后加速组疗效明显高于常规组 (P <0 .0 5 ) ,后加速组放疗副反应和并发症无明显增加 ,后加速组死于复发的比例比常规组低 ,分别为 10 .8% (4/37)和 36 .11% (13/36 ) (P <0 .0 5 ) ,两组的主要死因是局部复发 ,其次是远处转移 ,常转至肝和肺。结论 后加速组放疗技术对于食管癌患者的放射治疗 ,是一种比较合理有效的照射方法 ,不增加放疗副反应和并发症 ,能否提高食管癌的长期生长率 。
Objective To analysis the curative effect of post accelerative irradiation on esophogeal cancer.Methods 73 pathologically dignosed patients with esophageal cancer since April,1998 were randomized into conventional group(36 patients)and post accelerative guoup(37 patients).The irradiative dose of the conventional group was 180 CG/time/day;5 times/week and the total dose was 66.6GY in 7.4 weeks.The irradiative dose of the accelerate group was 180GY/time/day previously,5times/week and the total dose was 43.2GY/4.6 weeks,followed by 150 CGY/time,twice/day,and an interval of over 6 hours 10 times/seek,the total does was 67.2GY/6.4 weeks.Results It ended up with no significant difference of local control rate between the two groups.The one year survival rate and the local control rate of the post accelerate group was 86.5%(32/37)and 78.4%(29/37) respectively while the conventional group was 52.8%(19/36)and 50%(18/36)respectively.The curative effect of the post accelerative group was obviously better than that of the conventional group(P<0.05).No increasing side effect or complication was observed in accelerative group.The causes of death of the two groups were local recurrence and the distant metastasis, mostly in liver and lungs.Conclusions The post accelerative radiotherapy is more reasonable and effective in the treatment of the patients with esophageal cancer without increasing the side effect of the radiotherapy and complications.It needs to be further studied whether it can prolong the long term survival of the patients with esophageal canceror not.
出处
《中国肿瘤临床与康复》
2001年第2期97-98,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
后加速放疗
食管癌
生存率
局控率
治疗
post accelcrate radiotherapy
cancer of the esophagus
the survival rate
local control rate
