摘要
目的 :分析甲状腺癌增殖细胞核抗原 (PCNA)、胚胎性抗原 (CEA)表达情况 ,提供临床预后参考。方法 :采用S P法免疫组织化学技术 ,以石蜡包埋切片免疫染色。结果 :2 8例甲状腺癌患者组织学类型的PCNA ,乳头状癌 +、 分别为 66.67%和 33.33% ;滤泡状癌分别为 4 2 .86%和 57.14% , 均为0。髓样癌 和 分别为 66.67%和 33.33% ,未分化癌为 33.33%和 66.67%。CEA的阴性率为2 8 57% ,阳性率为 71 4 3% ,其中 +和 占 85% , 占 15% ,15%中主要为髓样癌和未分化癌的组织学类型。结论 :甲状腺癌的恶性程度与PCNA、CEA表达强度有密切关系。检测PCNA、CEA表达强度作为判断甲状腺癌的恶性程度及评估预后 ,具有临床的实际意义 。
Objective To analyze the expression of proliferative cell nuclear antigen(PCNA),carcinoembryonic antigen(CEA) in thyroid cancer of clinical pronosis.Methods Paraffin embedding slides were stained by S P immunohistochemistry.Results Among 28 thyroid carcinama cases,the positive rates were as fellows:papillary carcinoma cancer +, were 66.67% and 33.33%;Follicula cancer were 42.86% and 57.14%, was 0;Medullary cancer ,were 66.67% and 33 33%;Undifferentiated cancer were 33.33% and 66.67%.The negative rate of CEA was 28.57%,the positive rate was 71.43%,among which 85% were + and ,15% was ,the histological types of the latter were mainly mudullary cancer and undifferentiated histology type.Conclusions The maliganant degree of thyroid carcinama has close relations with the expression intensity of PCNA and CEA.Testing its expression intensity has clinical and practical significance.It can provide reference in treatment.
出处
《肿瘤防治杂志》
2001年第1期12-14,共3页
China Journal of Cancer Prevention and Treatment
