摘要
[目的 ]研究福建省广州管圆线虫的特征 ,寻找有效的诊断方法和治疗措施。 [方法 ]调查全省各地的感染情况 ,用大白鼠作为动物模型进行实验感染 ,了解致病过程 ,检测血清抗体 ,观察药物杀虫效果。 [结果 ]福建省有广州管圆线虫的分布 ,终末宿主为褐家鼠 ,中间宿主为福寿螺和褐云玛瑙螺。人或动物经口感染 ,感染后立即侵犯宿主的中枢神经系统 ,2 0 d后发育成幼龄成虫 ,然后才开始转移到心、肺处。此时血清中的抗体也达到较高的水平 ,36 d后可在粪便中查到一期幼虫。阿苯哒唑和甲苯咪唑为有效的杀虫药物。 [结论 ]人们食用螺类有受广州管圆线虫感染的危险 ,应加强预防。
Objective] To study the characterization of the Angiostrongylus cantonensis in Fujian, find out its effective diagnosis method and treatment . [Methods] To investigate the distribution of A. cantonensis in Fujian,set up an animal model of experimental infection,observe the pathogenic cause, detect the antibodies in the host serum and test the effectiveness of drugs. [Results] There were A.cantonensis in Fujian. The terminal host was Rattus norvegicus and intermediate hosts were Ampullarum crossean and Achatina fulica. The larva infected human and animal through mouth and invaded the central nervous system immediately. 20 days later,the young adult immigrated to the heart and lung,the serum antibody reached to higher levels. 36 days later, the first stage larva was found in the faeces. The Mebendazole and Albendozole were the effective drugs. [Conclusion] There is possibility of A. cantonensis infection by food source and prevention measures should be carries out.
出处
《海峡预防医学杂志》
CAS
2001年第1期11-14,共4页
Strait Journal of Preventive Medicine
基金
福建省科技厅科技项目! (2 0 0 0 Z1 64)
福建省卫生厅跨世纪学术和技术带头人基金
关键词
广州管圆线虫
分布调查
实验感染
抗体检测
药物杀虫
angiostrongylus cantonensis
distribution
experimental infection
antibodies detecting
effective drug
