摘要
目的研究水溶性壳聚糖对抗肿瘤活性因子和NK细胞活性的影响。方法分别用不同浓度水溶性壳聚糖腹腔注射荷瘤小鼠 ,然后测定巨噬细胞一氧化氮 (NO)、肿瘤坏死因子 (TNF)的生成 ,以及脾细胞γ 干扰素(IFN γ)和NK细胞活性。结果水溶性壳聚糖有显著地促进荷瘤小鼠NO、TNF、IFN γ的生成 ,提高NK细胞活性。与对照相比P <0 .0 1。结论水溶性壳聚糖能提高荷瘤小鼠的免疫功能。
PurposeThe aim is to study the effects of soluble chitosan on antitumor factors and NK cell activity in rats.MethodsThe level of NO、TNF produced by peritoneal macrophages,IFN γ production and NK cell activity of spleen was detected,after different concentrations of chitosan were injected into the sarcoma 180 rats peritoneally.ResultsThe contents of NO、TNF、IFN γ and NK cell activity in sacroma 180 rats were significantly higher in the chitosan groups than those in the control group ( P <0.01).ConclusionChitosan could impove the immune function in rats.
出处
《中国生化药物杂志》
CAS
CSCD
2001年第1期21-22,共2页
Chinese Journal of Biochemical Pharmaceutics
