摘要
:目的 :研制甲磺酸培氟沙星滴眼液。方法 :采用紫外分光光度法测定含量。对170例门诊眼部重症感染患者应用该滴眼液后进行疗效观察。结果 :线性范围为2～14μg/ml,回归方程为A=0.1018C,r=0.9999(n=7)。该方法测得平均回收率为99 64 % ,RSD为0 43 %。经治疗痊愈150例 ,有效16例 ,无效4例 ,总有效率达97 6 %。结论 :该滴眼液疗效确切 ,紫外分光光度法测定含量方法简便、快速、准确 。
OBJECTIVE:To prepare pefloxacin mesylate eye drops.METHODS:The content of pefloxacin was determined with UV-spectrophotometry.The therapeutic effect of the eye drops was observed in 170 out-patients.RESULTS:The linearity range was 2～14μg/ml with a regression equation of A=0.1 018C and r=0.9 999(n=7).The average recovery was 99.64% with a RSD of 0.43%.After treatment,150 out-patients recovered,16 out-patients improved and 4 out-patients had no efficiency with a total effective rate of 97.6%.CONCLUSION:The eye drops has definite therapeutic effect.The UV-spectrophotometry method is simple,rapid and accurate in determination of the content and no special reagent is needed.
出处
《中国药房》
CAS
CSCD
2001年第3期151-152,共2页
China Pharmacy
关键词
甲磺酸培氟沙星
滴眼液
制备
含量
测定
临床应用
pefloxacin mesylate
eye drops
preparation
determination of content
clinical use
