摘要
目的 探讨冠心病患者餐后血脂代谢情况。 方法 对 11例冠心病患者 (冠心病组 )和 15例健康者 (对照组 )予低脂饮食 2周后进食脂肪餐。于餐前、餐后 2、4、6、8h采血 ,检测血TG、TC、LDL C、HDL C、LPO及LDL C的氧化活性LPO LDL C。 结果 冠心病组餐前TG (P <0 .0 0 1)、LDL C(P <0 .0 1)极显著高于对照组 ,HDL C(P <0 .0 0 1)极显著低于对照组 ,LPO (P <0 .0 0 1)、LDL LPO C(P <0 .0 1)均极显著高于对照组。冠心病组餐后各点TG(P <0 .0 1)极显著高于对照组 ,HDL C(P <0 .0 0 1)极显著低于对照组 ,LPO(P <0 .0 0 1)、LDL LPO C(P <0 .0 0 1)极显著高于对照组。多元回归分析表明餐后血脂 (TG AUC)与冠心病发生密切相关。冠心病组餐后 8h的TG值 (P <0 .0 0 5 )显著高于餐前 ,餐后各时段LDL LPO C(P <0 .0 0 1)极显著高于餐前 ,对照组餐后各时段LDL LPO C(P <0 .0 0 1)极显著高于餐前。 结论 冠心病患者存在餐后高血脂 ,餐后高血脂与冠心病发生密切相关 ,冠心病患者餐后LDL C代谢异常 ,对氧化剂敏感性增强 ,脂质过氧化物明显增加。
Objective To study the postprandial lipid metabolism in patients with coronary heart disease. Methods 11 CHD cases as CHD group and 15 normal as control group were selected to undergo oral fat load test. Blood samples were obtained before test and 2,4,6 and 8 hours after test. Serum TG, TC, LDL-C,HDL-C, LPO and LDL-LPO-C were calculated. Results 1.Preprandial TG, LDL-C, LPO and LDL-LPO-C in CHD group were significantly higher than that of control group. 2. Postprandial TG, LPO, LDL-LPO-C in CHD group were significantly higher than that of control group. Postprandial HDL-C in CHD group were significantly lower than control group. 3. Postprandial TG (8h), LDL-LPO-C in CHD group were significantly higher than in the preprandial. Postprandial LDL-LPO-C in control group was significantly higher than preprandial. Conclusions 1. Postprandial high-lipemia and dyslipemia was obvious in CHD group. 2. Postprandial high-lipemia was closely related to the development of CHD. 3. Postprandial LDL-LPO-C in CHD group increased significantly and LDL-C sensitivity to oxidative intensified with postprandial time. 4. Postprandial LPO in CHD group increased significantly.
出处
《中国临床营养杂志》
CAS
2001年第1期35-38,共4页
Chinese Journal of Clinical Nutrition
关键词
冠心病
口服脂肪负荷试验
餐后血脂
过氧化脂质
Coronary heart disease
Oral fat load test
Postprandial lipemia
Lipid peroxidates
