摘要
目的 探讨心房纤颤患者的心房肌细胞是否存在细胞凋亡。方法 利用EdUTP缺口末端标记技术染色和透射电镜观察心房纤颤患者的心房肌组织。结果 心房纤颤患者心房肌少数细胞核不规则 ,核膜有皱褶 ,染色质凝集成颗粒状 ;细胞器密度增加 ,肌原纤维固缩或坏死 ,线粒体脱嵴 ,溶酶体和心钠素颗粒增多 ;有些细胞膜有皱褶。心肌细胞间胶原纤维和纤维细胞增多 ,有些纤维细胞的染色质在核膜下凝集明显。结论 心房纤颤状态下 ,有少部分心肌细胞和纤维细胞有凋亡现象 ,这可能不是房颤的病因而是房颤的结果。
Objective To research whether the apoptosis of atrial cells are existance in patient with atrial fibrillation. Method The atrial muscle tissue from patients with atrial fibrillation was stained using EdUTP -in situ end-labeling and observed by electric microscopy. Results A few of nuclei of atrial cells were irregularity, some nuclear membrane were rugose, and agglutinative granule of chromatine can be observed. The cell organs were increased in density, and myofibrilla were pyknosis or necrosis, the mitochondrial cristae were decreased.The lysosome and cardionatrin granule were enhanced. Some rugose of cytomembranes can be seen. Collagenous fibers and fibrous cells among atrial cells were increased. The chromatin of some fibrous cell were agglutinated obviously beneath nuclear membrane. Conclusion The apoptosis,which may be the result but not cause of fibrillation, is exstence in a few atrial cell and fibrous cell of patient with fibrillation.
出处
《新乡医学院学报》
CAS
2001年第1期1-3,共3页
Journal of Xinxiang Medical University
基金
河南省教委资助课题 !(99310 0 13)
关键词
心房纤颤
心肌细胞
细胞凋亡
电镜
病理
atrial fibrilltion
myocardial cell
apoptosis
electron microscope
