摘要
的研究骨髓坏死的临床意义。方法从 1995年至今，我院已发现骨髓坏死 5例，我们对这些病例的临床表现及诊断进行描述和分析。结果这 5例骨髓坏死的原发病均为恶性疾病 (2例胃癌， 1例肺癌， 1例急性淋巴细胞白血病， 1例多发性骨髓瘤 )，临床上有骨痛，贫血和发热。所有病例均有贫血，平均血红蛋白 <60g/L，白细胞 (2.9～ 26.3)× 109/L，血小板减少。血清乳酸脱氢酶 (518～ 2417U/L)及碱性磷酸酶 (142～ 265U/L)均增高。骨髓象显示骨髓中组织和基质的大片坏死。结论骨髓坏死是一个少见的临床综合征，其后常隐藏着恶性疾病，预后差。
Objective To study the clinical significance of the bone marrow necrosis. Methods The clinical feature and diagnosis of 5 patients with bone marrow necrosis were analysed. Results the five cases of bone marrow necrosis were in association with malignant diseases (2 gastric cancer, 1 lung cancer,1 acute lymphoblastic leukemia, 1 multiple myeloma).These patients presented with bone pain, anemia and fever. Analyses gave evidence of anemia in all cases, with a mean Hb<60g/L, white blood cell (WBC)(2.9～ 26.3)× 109/L,and with a decrease of platelet. Biochemical data proved an increase of LDH(518～ 2417)U/L,and an increase in alkaline phosphatase(142～ 265)U/L.Bone marrow aspirate revealed all patients necrotic bone marrow particles with distended sinusoids and necrotic eosinophile material. Conclusions The bone marrow necrosis is infrequently diagnosed during life, and most frequently reported in association with malignant diseases, and its presence often signifies a poor prognosis.
出处
《罕少疾病杂志》
2001年第1期10-12,共3页
Journal of Rare and Uncommon Diseases
