摘要
本文合成出九种新的BAT(双-氨基乙硫醇)类衍生物,并研究^(113m)In-BAT系列配合物的动物分布,得到心肌吸取量与配合物脂溶性之间的定量关系。实验表明,配合物B的心/血、心/肺比值高,是最有希望的心肌显像剂。此外,还首次测得了BAT-TE配体及In-BAT-TE和In-BAT-ETE两种配合物的晶体结构。
In this paper, some new BAT derivatives are designed and synthesized in order to find some ideal myocardial imaging agents. These ligands form penta-coordinated complexes with indium cation. The structures of ligand BAT-TE and complexes In-BAT-TE and In-BAT-ETE are determined by X-ray crystallography at first. Biodistribution shows that the higher lipophilicity of complex induces apparently higher myocardial accumulation. Up to date, complex B is the best 113mIn-labeled myocardial imaging agent. It is also suited to 111In.
出处
《核化学与放射化学》
CAS
CSCD
北大核心
1991年第4期223-232,共10页
Journal of Nuclear and Radiochemistry
关键词
心肌显像剂
^113mIn-BAT
晶体结构
(113)~mIn-BAT complex, BAT ligand, Crystal structure, Myocardial imaging agent, Partition coefficient,
