摘要
观察了6名19～21岁男性健康受试者,头低位-6°卧床8天生理生化指标昼夜节律特性的变化。结果:心输出量、脉压和去甲肾上腺素日平均水平显著下降;外周阻力、尿中的Na^+、K^+和皮质醇含量显著增加。这表明,卧床使心血管功能减弱,交感神经兴奋性下降,水盐代谢紊乱。从心输出量和去甲肾上腺素之间的中度正相关关系,可以推测去甲肾上腺素对卧床期心输出量的调节可能起着重要作用。
Six healthy male volunteers aged 19—21 were selected as test subjects. The schedule of experiments included a 3—day control period ( pre—HDT), a 8—day bed rest period with head down tilt of —6°(HDT—6°) and a 5—day recovery period (post—HDT). Physiological parameters (SV, CO,HR, BP, TFI, EVI, LVET) were measured four times and norepinephrine (NE), epinephrine (E), potassium (K^+), sodium (Na^+) and cortisol excretion in urine were assayed six times daily in the experiment. The results indicated that SV, CO, pulse pressure and NE excretion decreased significantly and peripheral resistance, K^+, Na^+ and cortisol excretions increased markedly during HDT—6°. Circadian rhythmic changes of the cardiovascular and biochemical parameters were also observed. The fact that there was a positive correlation with medium significance between cardiac output and NE reflects that NE might play an important role in the control of CO during bed rest.
出处
《航天医学与医学工程》
CAS
CSCD
1991年第4期259-267,共9页
Space Medicine & Medical Engineering
关键词
卧床试验
生理反应
昼夜节律
失重
bed rest, simulated weightlessness, circadian rhythmic change
