期刊文献+

IL-18与疾病相关性的实验研究进展 被引量:7

暂未订购
导出
摘要 白细胞介素 18 (IL- 18)可诱生 IFN- γ,加强 Fas L介导细胞毒效应 ,增强 IL- 2、GM- CSF的活性 ,促进 TNF、IL- 1、ICAM- 1、IL- 8的表达 ,诱生 IL- 4 ,与 IL- 12有协同作用。 IL- 18有增强免疫、抗肿瘤作用 ,并参与某些自身免疫病、变态反应性疾病的发生。本文综述了现阶段 IL- 18相关疾病的实验研究 ,并展望其应用前景。
出处 《国外医学(预防.诊断.治疗用生物制品分册)》 2001年第1期26-29,共4页 Foreign Medical Sciences(Section of Bilogics for Prophylaxis,Diagnosis and Therapy)
  • 相关文献

参考文献16

  • 1Yoshimoto T et al. Proc Natl Acad Sci USA, 1999;96(24): 13962-13966
  • 2Rothe H et al. J Immunol, 1999; 163(3):1230-1236
  • 3Furlan R et al. J Immunol, 1999; 163(5):2403-2409
  • 4Hu HZ et al. Immunology, 1999; 98(3):379-385
  • 5Wild JS et al. J Immunol, 2000; 164(5):2701-2710
  • 6Seki S et al. Immunol Rev, 2000; 174:35-46
  • 7Barreios AP et al. Scand J Immunol, 2000; 51(5):472-478
  • 8Ohkusu K et al. Infect Immun, 2000; 68(5):2449-2456
  • 9Xing Z et al. J Immunnol,2000; 164(5):2575-2584
  • 10Tanaka-Kataoka M et al. Cytokine, 1999; 11 (8):593-599

同被引文献54

  • 1张建国,刘晓莉.HA型血液灌流器与透析器串联治疗尿毒症病人的临床观察[J].中国血液净化,2002,1(1):31-34. 被引量:53
  • 2任晓风,吴莲波,王伟明,逄淑华,吴秉纯.四君子汤对脾气虚证调节作用的实验研究[J].中国中医药科技,2005,12(6):359-360. 被引量:28
  • 3温庆祥,古颖.四君子汤对脾虚患者免疫功能影响[J].北京中医,2006,25(4):239-240. 被引量:43
  • 4HARA I, NAGAI H, MIYSKE H, et al. Effectiveness of cancer vaccine therapy using cells transduced with the imterleukin-12 gene combined with systemic interleukin-12 administration [ J ]. Cancer Gene Ther, 2000, 7 ( 1 ) : 83 - 90.
  • 5HYODO Y, MATSUI K, HAYASHI N,et al. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor [ J ]. Immunol, 1999, 162 (3) : 1662 - 1668.
  • 6Okamura H,Tsutsi H,Komatsu T,et al.Cloning of a new cytokine that induces IFN-gamma production by T cell.Nature,1995,378 (6552):88.
  • 7Losy J,Niezgoda A.IL-18 in patients with multiple sclerosis.Acta Neurol Scand,2001,104(3):171.
  • 8Jander S,Stoll G.Differential induction of interleukin-12,interleukin-18,and interleukin-1 beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat.J Neuroimmunol,1998,91 (1 -2):93.
  • 9Jander S,Stoll G.Increased serum levels of the interferon-gamma-inducing cytokine interleukin-18 in myasthenia gravis.Neurology,2002,59(2):287.
  • 10Im SH,Barchan D,Maiti PK,et al.Suppression of experimental myasthenia gravis,a B cell-mediated autoimmune disease,by blockade of IL-18.FASEB J,2001,15(12):2140.

引证文献7

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部