摘要
目的 研究骨肉瘤组织中 CD44 v6 的表达情况 ,探讨它与骨肉瘤侵袭的关系及临床意义。 方法 应用免疫组织化学方法对 70例骨肉瘤、15例骨软骨瘤患者和 15例正常人的骨组织进行 CD44 v6 、ki- 6 7检测 ;对 6 0例有随访资料的病例进行生存分析。 结果 CD44 v6 在骨肉瘤中普遍呈阳性表达 ,明显高于骨软骨瘤及正常骨组织 ,与预后无明显相关 ,与细胞增殖指数 ki- 6 7无明显相关。 结论 CD44 v6 可作为骨肿瘤恶性表型的标志 ,并可作为骨肉瘤诊断的辅助指标 ;CD44 v6 不是决定肿瘤细胞增殖。
Objective\ Investigation of the expression of CD\-\{44v6\} in normal bone tissues, exostosis and osteosarcoma specimens, and the relationship between the expression and clinical pathology of osteosarcoma.\ Methods\ The expression of CD\-\{44v6\} and ki\|67 were evaluated immunohistochemically in 15 normal bone tissues, 15 exostosis and 70 osteosarcoma.\ Results\ The expression of CD\-\{44v6\} in osteosarcoma was markedly higher than those in normal bone tissues and exostosis.\ It had no relation to the prognosis.\ Conclusion\ CD\-\{44v6\} may act as a symbol of malignant phenotype of the bone tumors.\ But it is not the only factor which decide the faculty of invasion and metastasis of malignant bone tumors.
出处
《福建医科大学学报》
2001年第1期24-25,F003,共3页
Journal of Fujian Medical University
