摘要
本文使用丙丁酚治疗５／６肾切除（Ｎｘ）大鼠，观察它对残余肾单位抗氧化酶的影响。结果发现，丙丁酚不但能改善５／６Ｎｘ大鼠残余肾小球的抗氧化酶活性，ＳＯＤ和ＧＳＨ－Ｐｘ活性均明显升高，代表氧自由基产生的ＭＤＡ水平下降；而且能使５／６Ｎｘ大鼠尿蛋白排泄量减少、肾功能改善及病理上肾小球硬化性病变和小管间质损害减轻。本实验提示５／６Ｎｘ大鼠残余行单位抗氧化酶的缺乏可加速慢性肾功能不全的进展，抗氧化剂——丙丁酚可增强残余肾单位的抗氧化酶活性，结果使５／６Ｎｘ大鼠慢性肾功能不全及肾脏病理损害均有改善。
o study theeffect of probucol on the antioxidant en-zymes
(AOEs) and its role in the rat with5/6 subtotal nephrectomy (Nx), 5/6Nxrats were fed rat chow
diet with (5/6 Nx+P) or without (5/6 Nx) the addition of 1%probucol. 5/6 Nx+P rats had a
significant-ly higher activity of glomerular AOEs-SODand GSHPx and lower level of
glomerularMDA, and also had a lower proteinuria,higher creatinine clerance. The
glomeru-losclerosis and tubular interstitial lesionswere markedly lessen as compared with
thatof 5/6 Nx rats. These results indicate theinadequacy AOEs of surviving glomerulimay paly
a role in the progression of chronicrenal failure. Probucol had preventing ef-fects on both the
renal function imparimentand the histological damage,through its ef-fect on AOEs of glomeruli
in rat of subtotalnephrectomy.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1995年第1期9-13,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
