摘要
应用免疫组化、免疫荧光和HBV-DNA原位杂交技术,从银屑病皮损处活检组织中检出了乙型肝炎病毒成份。观察组75例,检出HBsAg12例,HBeAg4例、HBcAg7例,HBV-DNA1例。总检出阳性病例为15例,占20％。乙型肝炎病毒成份分布在皮肤各层中。角化层、粒细胞层各3例、棘细胞层9例、基底细胞层7例,真皮层3例。此结果提示乙型肝炎病毒在银屑病发病中可能起重要作用。
Using the technique of immunohistochemistry,immunofluorescence and in situ DNA hybridization,the authors were capable of detecting hepatitis B virus component in the cutaneous lesion of psoriasis.In a total of 75 cases,HBsAg,HBeAg,HBcAg and HBV-DNA were found in 12,4,7 and 1 cases,respectively.The total positive rate was of 15/75 or 20%.The distribution of the HBV component covered the entire layers of the skin.It was found in stratum corneum in 3 cases,in stratum gra-nulosum in 3,in stratum spinosum in 9,in stratum basale in 7,and in dermis in 3.The result suggested that HBV might play an important role in the pathogenesis of psoriasis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1989年第6期414-416,共3页
Medical Journal of Chinese People's Liberation Army
