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C-met、P_(53)蛋白在脑星形细胞瘤中的表达

The expression of C-met and P_(53) protein in brain astrocytoma
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摘要 目的 探讨 C- met、P5 3蛋白在人脑星形细胞瘤中的表达 ,并探讨其与脑肿瘤发生、发展及预后的关系。方法 应用 C- met、P5 3蛋白的抗体对 90例人脑星形细胞瘤进行了免疫组织化学染色。结果 在星形细胞 C- met、P5 3均有表达 ,高级别星形细胞瘤中 C- met、P5 3也有表达。结论 C- met和 P5 3表达与星形细胞瘤的发生、发展有关 ,C- met和 P5 3 免疫组化的表达有助于了解 C- met和 P5 ? Objective To disscuss the expression of C met and P 53 protein in human brain astrocytoma and it's relationship with the occurance,develepment and prognosis of tumors.Methods Immunohistochemical staining technique was undertaken to detect antibody of C met and P 53 protein in ninty cases of astrocytoma.Results There were expressions of C met and P 53 in all astrocytomes even in much higher grade ones.Conclusions There's pertinence between the expression of C met and P 53 protein and occurance development in astrocytoma.The immunohistochemical expression of C met and P 53 contributes to the understanding of the functions of C met and P 53 in tumor tissues. 〔
出处 《中国老年学杂志》 CAS CSCD 北大核心 2001年第2期85-86,共2页 Chinese Journal of Gerontology
关键词 C-MET P_(53) 星形细胞瘤 免疫组化 C-met P_(53) Astrocytoma Immunohistochemitry
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参考文献5

  • 1Morivama T,kataoka H,Tsubouchi H etal.Concomitantexpressionof hepatocyte growth factor (HGF) ,HGF activator and C- metgenes in human gliomas cells in vitro〔J〕[].FEBSLect.1995
  • 2Cooper CS,Park M,Blair DG et al.Molecular cloning of a new transforming gene from a chemically transformed human cell line〔J〕[].Nature.1984
  • 3Battaro DP,Rubin JS,Faletto DL et al.Identification of the receptor encoded by the proto-oncogene C-met 〔J 〕[].Oncegene.1990
  • 4Naldini L,Vigna E,Narsimhan R et al.Hepatocyte growth factor(HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene C-met 〔J〕[].Oncegene.1991
  • 5Mashiyama S,Murakami Y,Yoshimoto T et al.Detection of P53 gene mutations in human brain tumors by single strand conformation polymorphism analysis of polymerase chain reaction products〔J〕[].Oncegene.1991

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