摘要
目的了解伴雷诺现象 (RP)的系统性红斑狼疮 (SLE)患者的临床特征。方法对近 4年在我院住院的 42例伴 RP的 SLE患者进行临床分析，并与 116例无 RP的 SLE患者进行对照。结果与无 RP组相比 ,有 RP组出现脱发、肌炎 /肌病、心脏受累和肺动脉高压的几率明显增高 (分别为 56.90％～ 83.33％， 9.48％～ 23.81％， 29.31％～ 59.52％， 1.72％～ 21.43％， P< 0.05或 0.01)。γ－球蛋白升高，抗核抗体、抗 RNP及抗 Sm抗体的阳性率也明显增高 (分别为 50.52％～ 73.68％ , 68.47％～ 87.80％ , 24.04％～ 70.00％ , 7.69％～ 35.00％ , P< 0.05或 0.01)。而两组患者在肾炎、神经系统受累及血液系统受累的发生率差异无显著性 (P均 >0.05)。对 125例患者进行了平均 2.15年的随访，其中包括全部的 11例肺动脉高压患者，死亡 3例，其中 1例死于肺动脉高压并发右心衰竭（有 RP组）。结论 SLE患者出现雷诺现象提示较易发生肺动脉高压、心脏受累和免疫学异常，对伴雷诺现象的 SLE患者应注意其心肺状态，以便早期诊断和治疗。
Objective To study the clinical features of the patients with systemic lupus erythematosus (SLE) with Raynaud′ s phenomenon. Methods The clinical manifestations and laboratory findings of 42 SLE patients with Raynaud′ s phenomenon were analyzed and compared with those of 116 SLE patients without Raynaud′ s phenomenon. Results As compared with SLE patients without Raynaud′ s phenomenon, the SLE patients with Raynaud′ s phenomenon were more likely to have myalgia/myopathy(9.48％ vs 23.81％ , P< 0.05), alopecia(56.90％ vs 83.33％ , P< 0.01), pulmonary hypertension(1.72％ vs 21.43％ , P< 0.01), cardiac involvement(29.31％ vs 59.52％ , P< 0.01), elevated serum level of gamma-globulin(50.52％ vs 73.68％ , P< 0.05), positive antinuclear antibodies(68.47％ vs 87.80％ , P< 0.05),positive anti-RNP antibodies (24.04％ vs 70.00％ , P< 0.01) and positive anti-Sm antibodies(7.69％ vs 35.00％ , P< 0.05). There were no significant differences in nephritis, neuropsychiatric and hematologic alterations between two groups. Among the 11 SLE patients with pulmonary hypertension, 3 patients died and 1 of them died of secondary heart failure, during 26-month follow-up. Conclusions The Raynaud′ s phenomenon in SLE patients seems susceptible to pulmonary hypertension, cardiac involvement and immunologic abnormalities. The function of heart and lung and pulmonary hypertension should be paid attention to in these cases.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2001年第1期12-14,共3页
Chinese Journal of Dermatology
