摘要
目的探讨两型亚急性皮肤型红斑狼疮（ SCLE）患者病情演变的差异。方法对 40例 SCLE患者进行 3～ 14年的随访分析，比较两型 SCLE患者临床表现和实验室检查异常变化、治疗反应及预后。结果在随访中，环形红斑型患者的疹型变化较少，病情较轻，部分患者出现干燥症状；而丘疹鳞屑型患者中大部分逐渐演变成 SLE。环形红斑型患者仅 21.7％发生轻度肾脏受累，皮质类固醇用量较小，无死亡病例；丘疹鳞屑型患者中 64.7％发生肾脏受累，皮质类固醇用量较大或合并使用免疫抑制剂， 1例死亡， 3例发展为尿毒症。结论环形红斑型是 SCLE中较为良性的一型，预后较好，而丘疹鳞屑型则易发展为 SLE，预后较差。
Objective To investigate the prognosis of two subtypes of subacute cutaneous lupus erythematosus (SCLE). Methods Forty patients with subacute cutaneous lupus erythematosus were followed-up for 3 to 14 years. The clinical and laboratory findings, the response to treatment and the prognosis in these cases were comparatively analyzed. Results During the follow-up period, the patients with annular erythema subtype of SCLE showed recurrent annular skin lesions and mild systemic manifestations. Some patients gradually developed sicca symptoms. On the other hand, most patients with papulosquamous subtype of SCLE developed systemic LE manifestions. 21.7％ of the patients in the annular erythema group had mild nephritis which could be controlled by lower dose of corticosteroids and no patients died. However, 64.7％ of the patients in the papulosquamous group had moderate to severe lupus nephritis, which required higher dose of corticosteroids or immunosuppressive agents to control. Among them, One patient died and 3 patients developed uremia. Conclusion Annular erythema subtype of SCLE is milder and has a better prognosis than that of papulosquamous subtype.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2001年第1期9-11,共3页
Chinese Journal of Dermatology
