摘要
目的 研究国产商品血竭的活性成分。方法 用甲醇提取 ,SephadexL 2 0 ,MCIgel和硅胶柱色谱进行分离纯化 ,用现代波谱学方法进行结构鉴定。结果 从国产雨林牌血竭的甲醇浸提物中得到 9个查耳酮化合物 ,分别鉴定为 :1 [5 (2 ,4,4′ 三羟基二氢查耳酮基 ) ] 1 对羟基苯基 3 (2 甲氧基 4 羟基苯基 ) 丙烷 (1) ,2′ methoxysocotrin 5′ ol (2 ) ,socotrin 4′ ol (3) ,2 甲氧基 4,4′ 二羟基二氢查耳酮 (4 ) ,2 ,4,4′ 三羟基二氢查耳酮 (5 ) ,2 ,4,4′ 三羟基 6 甲氧基二氢查耳酮 (6 ) ,2′ ,4′ ,4 三羟基查耳酮 (7) ,2 甲氧基 4,4′ 二羟基查耳酮 (8) ,2′ 甲氧基 4′,4 二羟基查耳酮 (9)。结论 1为一新的查耳酮二聚体 ,命名为剑叶血竭素 (cochinchinenin) ,2 - 9为首次从该血竭中分离得到。
AIM To study the active constituents of Dracaena cochinchinensis (Lour.) S.C.Chen. in the commercial dragon blood. METHODS Various column chromatographies with Sephadex L 20 gel, MCI gel and silica gel were employed for the isolation and purification. The structures of compounds were elucidated by spectral analysis. RESULTS Nine chalcones were isolated from the commercial dragon's blood which was made of D.cochinchinensis (Lour.) S.C.Chen.. By means of spectral data, they were identified as 1 [5 (2,4,4′ trihydroxydihydrochalconyl)] 1 ( p hydroxyphenyl) 3 (2 methoxy 4 hydroxy phenyl) propane (1), 2′ methoxysocotrin 5′ ol (2), socotrin 4′ ol (3), 2 methoxy 4,4′ dihydroxydihydrochalcone (4), 2,4,4′ trihydroxy dihydrochalcone (5), 2,4,4′ trihydroxy 6 methoxydihydrochalcone (6), 2′,4′,4 trihydroxy chalcone (7), 2 methoxy 4,4′ dihydroxychalcone (8) and 2′ methoxy 4′,4 dihydroxychalcone (9). CONCLUSION Compound 1 is a new chalcone dimer and named as cochinchinenin. Compounds 2-9 were isolated from D.cochinchinensis (Lour.) S.C.Chen. for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2001年第3期200-204,共5页
Acta Pharmaceutica Sinica
基金
云南省科委应用基础研究基金资助项目! (97CO37Q)
