摘要
目的用磁共振质子波谱 (MRS)的方法研究 Alzheimer病 (Alzheimer disease,AD)内侧颞叶代谢的改变，试图为临床诊提供客观依据。方法对 15例 AD病人和 15例正常老年人的内侧颞叶进行磁共振质子波谱 (MRS)(采用 STEAM序列 )采集。并对代谢产物的变化与临床简易精神测量评分 (MMSE)之间和与海马结构体积测量值之间进行相关性分析。结果 AD病人 NAA/Cr的降低与 MMSE评分和海马体积呈正相关， mI/Cr的升高与 MMSE评分和海马体积改变呈负相关。结论 MRS能无创性检查 AD脑部的代谢变化， 1H－ MRS所显示的 AD的 NAA降低和 mI升高能提高中早期 AD的诊断正确率。
Objective To study the metabolic alterations in medial temporal lobe of Alzheimer disease(AD) patients with proton magnetic resonance spectroscopy and provide base for clinical diagnosis.Method Proton magnetic resonance spectroscopy were performed in the medial temporal lobe in 15 AD patients and 15 healthy control using STEAM sequence.We also studied the correlation between the ratio of NAA/Cr， mI/Cr and MMSE,and the volume of hippocampal strucfture.Result Decreased ratio of NAA/Cr was positively related to MMSE score and volume of hippocampal sructure ,the increased ratio of mI/Cr was negatively related to MMSE and volume of hippocampal structure.Conclusion 1H- MRS could provide metabolic information of brain tissue noninvasively in AD patients in vivo.The combination of high mI and low NAA could improved diagnosis of AD.
出处
《现代康复》
CSCD
2001年第3期54-55,共2页
Modern Rehabilitation
关键词
阿尔茨海默病
磁共振质子波谱
代谢
Alzheimer disease (AD)
proton megnetic resonance spectroscopy(MRS)
metabolism
