摘要
本文研究了以二(三苯膦)苄基氯化钯为催化剂,以三丁基芳基(苄基)锡为试剂与二元酰氯交叉偶联合成二元酮化物的新方法,合成了十一种二元酮类化合物。该方法具有反应产率高、反应彻底、化学选择性强、易于操作.终点明显等特点。氧气能加速反应,而三苯基磷使反应减慢。对反应的催化剂、反应溶剂、反应温度和反应时间等进行了比较和选择,验证了该类反应的相对最佳条件。
New method is studied for synthesis of diketones with the cross-coupling reaction of tributylaryltin (tributylbenzyltin) reagents and diacetyl chlorides catalyzed by benzylchlorobis (triphenyl-phosphine),palladium in this paper,and synthesized 11 rinds of diketones.With this method,high yields of the cross-coupled products are obtained,the reaction is clean,the workup is simple,the chemoselectivity is high,and the reaction end is visible,too.Oxygen has an accelerating effect on the reaction, whereas triphenylphosphine can deactivited it.We have compared and chosen the catalyst,solvent,temperature,time of the reaction.We tested and verified the best reaction condition.
出处
《哈尔滨师范大学自然科学学报》
CAS
1992年第4期72-79,共8页
Natural Science Journal of Harbin Normal University
关键词
钯
催化
酰氯
有机锡化合物
二元酮
Pallladium catalyst
Reagents of diacetyl chloride and aganotin
Cross-coupling reaction
