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骨髓增生异常综合征患者骨髓细胞凋亡的初步探讨 被引量：3

Clinical significance of apoptosis of bone marrow cells in patients with myelodysplastic syndromes
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摘要 采用 TUNEL 法对 2 6例骨髓增生异常综合征 (MDS)、11例巨幼细胞贫血 (Meg A)、8例阵发性血红蛋白尿 (PNH)、6例 Evans综合征患者和 10例正常健康志愿者的骨髓单个核细胞 (BMMNC)凋亡进行探讨。结果发现 ,5 0 % MDS呈现凋亡过度 ,Meg A、PNH和 Evans综合征患者与对照组无显著差异。 MDS患者凋亡累及粒、红、巨三系各阶段造血细胞 ,随病情演变 ,凋亡程度渐下降。提示凋亡过度为 MDS无效造血机制之一 ,病情演变可能与异常克隆逃逸凋亡有关 ,抗凋亡疗法可试用于早期 MDS。 Apoptosis of bone marrow mononuclear cells(BMMNC)was demonstrated using terminal deoxytransferase(TdT)-mediated dUTP nick end labeling(TUNEL)method in 26 myelodysplastic syndromes(MDS)patients,11 megaloblastic anemia(MegA),8 paroxysmal nocturnal hemoglobinuria(PNH)and 6 Evans syndromes patients.Apoptosis was significantly increased in MDS,no difference of apoptosis was found between MegA,PNH,Evans syndromes and normal controls.Apoptosis was seen in myeloid blasts,maturing myeloid cells,nucleated erythroid cells and megakaryocyte cells in MDS patients.As MDS progressing,apoptosis gradually decreased.These results suggest that excess apoptosis is one of factors leading to ineffective hematopoiesis in MDS.MDS clinical progression may be associated with escaping from apoptosis of myelodysplastic progenitors.Therapy of anti-apoptosis could be used in early MDS patients.
作者 李大启 林果为 崔为发
机构地区 复旦大学医学院附属华山医院 潍坊医学院附属医院
出处 《山东医药》 CAS 北大核心 2001年第5期7-8,共2页 Shandong Medical Journal
关键词 骨髓增生异常综合征 细胞凋亡 骨髓单个核细胞 BMMNC Myelodysplastic syndromes Apoptosis Bone marrow
分类号 R551.302 [医药卫生—血液循环系统疾病]
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参考文献6

  • 1[1]Parker JE，Mufti GJ.Ineffective haematopoiesis and apoptosis in myelodysplastic syndromes.Br J Haematol，1998，101:220～230.
  • 2[2]Bennett JM，Catovsky D，Daniel MT，et al.Proposals for the classification of the myelodysplastic syndromes.Br Jhaematol，1982，51:189～199.
  • 3[3]Shetty V，Mundle S，Alvi S，et al.Measurement of apoptosis，proliferation and three cytokines in 46 patients with myelodysplastic syndromes.Leuk Res，1996，20:891～900.
  • 4[4]Oyake T，Ishida Y，Ito S，et al.Flow cytometric analysis of apoptotic progenitor cells in patients with myelodysplastic syndrome（MDS）.Blood，1999，94（suppl 1）:286.
  • 5[5]Parker JE，Fishlock KL，Mijovic A，et al.Low-risk myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro-versus anti-apoptotic bcl-2-related proteins.Br J Haematal，1998，103:1075～1082.
  • 6[6]Kitagawa M，Yamaguchi S，Takahash M，et al.Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplas-ia.Leukemia，1998，12:486～492.

同被引文献16

  • 1Bouscary D, De Vos J, Guesnu M, et al. Fas/apo- 1 (CD95) expression and apoptosis in patients with myelodysplastic syndromes[J]. Leukemia, 1997,11 : 839 - 845.
  • 2Parker JE, Mufti GJ, Rasool F, et al. The role of apoptosis, proliferation and the Bcl - 2 related proteins in the myelodysplastic syndromes (MDS) and acute myeloid leukemia secondary to MDS (MDS - AML)[J]. Blood,2000,96:3932 - 3928.
  • 3Kitagawa M, Yamaguchi S, Takahashi M, et al. Localization of fas and fas ligand in bone marrow cells demonstrating myelodys - plasia[J]. Leukemia, 1998,2:486 - 492.
  • 4Raza A, Mundle S, Shetty V, et al. Novel insights into the biology of myeiodysplastic syndrome : excessive apoptosis and the role of cytokines[J]. Int J Hematol, 1996,63:265 - 278.
  • 5Boula A, Voulgare M, Giannouli S, et al. Effect of cA2 anti - tumor necrosis factor - alpha antibody therapy on hematopoiesis of patients with myelodysplastic syndromes[J]. Clin Cancer Res ,2006,12(10) :3099 - 3108.
  • 6Cortelezzi A, Cattaneo C, Sarina B, et al. Efficacy of N - acetylcysteine and all - trans retinoic acid in restoring in vitro effective hemopoiesis in myelodysplastic syndromes[J]. Leuk Res, 1999,24: 129- 137.
  • 7Kim MK, Lee JL, Cho HS, et al. The hematologic response to anti - apoptotic cyto kine therapy : results of pentoxifylline, ciprofloxacin, and dexamethasone treatment for patients with myelodysplastic syndrome [J]. J Korean Med Sci, 2006,21 ( 1 ) : 40 - 45.
  • 8Moroni M, Porta C, Invemizzi R, et al. TUNEL evidence of reduced bone marrow cells apoptosis in a refractory anemia patient treated with amifostine [J]. Br J Haematol, 1999,104: 420- 425.
  • 9Parker JE, Mufti GJ. Ineffective haemapoiesis and apoptosis in meylodysplastic syndrome[J]. Br J Haematol , 1998,101 : 220.
  • 10Rosenfeld C, List A. A hypothesis for the pathogenesis of meylodysplastic syndrome : implication for new therapies[J]. Leukemia ,2000,14:2-8.

引证文献3

二级引证文献1

山东医药
2001年 第5期

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