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海洛因依赖患者肌红蛋白测定的临床意义

Clinical Significance of Myoglobinuria and Serum Myoglobin in Heroin-addicted Patients
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摘要 探讨海洛因依赖患者急性横纹肌溶解症 (rhabdomyolysis)与肌红蛋白尿的关系。用放射免疫法检测 10 6例海洛因依赖患者血清和尿液中的肌红蛋白水平 ,并将其与 30名正常健康者的作比较。海洛因依赖患者戒毒头3天血、尿肌红蛋白水平明显升高 ,2周左右肌红蛋白水平逐渐下降但仍高于对照组 (P <0 .0 1) ,一个月肌红蛋白水平趋于正常 (P >0 .0 5 )。从尿中检测肌红蛋白是早期发现海洛因致急性横纹肌溶解症的简便而重要的方法。 The article is to study the relationship between myoglobinuria and acute rhabdomyolysis in heroin-addicted patients. The levels of myoglobin in serum and urine were determined by RIA in 106 heroin-addicted patients and 30 healthy volunteers who were selected as the controls. The levels of myoglobin in serum and urine increased significantly in heroin-addicted patients in 3 days after giving up heroin, and gradually decreased in 2 weeks but still higher than the levels of the controls( P <0.01). The levels became normal in 1 month( P >0.05). Urine myoglobin detection is a simple and effective method to find out acute rhabdomyolysis derived from heroin addiction early.
出处 《标记免疫分析与临床》 CAS 2001年第1期10-11,共2页 Labeled Immunoassays and Clinical Medicine
关键词 海洛因依赖 肌红蛋白 急性横纹肌溶解症 放射免疫分析 Heroin Addiction Myoglobin Acute rhabdomyolysis
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参考文献6

  • 1Gibb W R G,Shaw I C.Myoglobinuria due to heroin abuse[].Journal of the Royal Society of Medicine.1985
  • 2Hsu SM,Werner A,Gayle Griffiths P A.Demonstration of myoglobin in formalin-fixed renal section by immunoperoxidase technic[].American Journal of Clinical Pathology.1982
  • 3Nicholls Niall J F,Moram J E.Rhabdomolysis and renal failure[].Medical Journal of Australia.1982
  • 4Koffler A,Friedler R M,Massry S G.Acute renal failure due to nontraumatic rhabdomyolysis[].Annals of Internal Medicine.1977
  • 5Richter R E,Challenor Y B,Pearson J.Acute myoglobinuria associated with heroin addiction[].The Journal of The American Medical Association.1971
  • 6Chan Y F,Wong P K,Chow T C.Acute myoglobinuria as a fatal complication of heroin addiction[].American Journal of Forensic Medicine and Pathology.1990

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