摘要
目的 探讨磁场对小鼠血清一氧化氮 (NO)生成及对小鼠生长发育的影响。方法 将小鼠置于同磁场 (3 0mT)不同曝磁时间 (3 0min、60min、1d、1周、1月 ) ,同时间 (60min)不同磁场 (10mT、2 0mT、3 0mT)中 ,观察磁场对小鼠血清NO含量的影响及小鼠活动状态、存活数、体质量变化。结果 在 3 0mT磁场中曝磁 60min ,NO含量明显增加 ,与对照组比较差异有显著性意义 (P <0 .0 1) ;曝磁 1d ,NO含量有所下降 ,但仍高于对照组 (P <0 .0 5 ) ;曝磁 1周、1月 ,NO含量则逐渐增高 ,明显高于对照组 (P <0 .0 0 1)及曝磁 60min、1d、1周组。同时随着曝磁时间的延长 ,小鼠活动减少 ,食欲减退 ,体质量下降 ,存活数减少。均曝磁 60min时 ,只有 3 0mT场强使NO含量显著增加 ,与对照组比较差异有非常显著性意义(P <0 .0 1) ,其它场强时NO含量无明显变化。该实验条件下 ,使NO含量增加 ,又可适当抑制其生成的最佳场强为 3 0mT ,作用时间为 60min。结论 磁场对NO生成有双向调节作用 :短时间曝磁 ,机体调节性NO生成增加 ,维持内环境稳定 ;长时间曝磁 ,NO生成过多 。
Objective To study the effect of magnetic field on nitric oxide (NO) in serum and growth of mice. Methods The mice were placed in same magnetic field (30 mT) but in different time (30 min,60 min,1 day,1 week,1 month) or in same time (60 min) but in different magnetic field (10 mT,20 mT,30 mT) to observe the effect of magnetic field on NO of mice serum, the change of activity, survivol number and body mass of mice. Results There was an obvious increase in NO level at 60 min after exposing to 30 mT magnetic field compared with the control group (P< 0.01 ). Although there was a decrease in NO level at 1 day after exposing to magnetic field the NO level was higher than the normal control group (P< 0.05 ). Continuely exposed to magnetic field for 1 week or 1 month the NO level was markedly increased (P< 0.001 ). At the same time,as time prolonged the mice activity and appetite of the mice were decreased with reduction of the body weight and survivol number. In the same time exposure of 60 min,only 30 mT magnetic field enhanced NO level,compared with the control group,there was a very significant difference(P< 0.01 ).Other kinds of magnetic field showed no significant influence on ON level.By the experiment it is proved that the optimal magnetic field enhancing NO level but proper inhibiting excess production of NO is 30 mT and suitable time is 60 min. Conclusion Magnetic field had a biphasic regulation on NO level. When mice was whith short time exposure to the magnetic field, NO level was enhanced and remained interior environment stability. But with long time exposure, NO produced rapidly and persistently affect the growth of mice.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2001年第1期35-37,共3页
Chinese Journal of Physical Medicine and Rehabilitation
