摘要
目的 :研究负荷变化对髁突软骨细胞蛋白多糖合成的影响。方法 :拔除成年家兔左下磨牙 ,分别于术后 2周、1月和 3月取双侧颞颌关节 ,进行阿辛兰和甲苯胺兰等组织化学染色和免疫组化染色。结果 :酸性粘多糖和蛋白多糖术后含量均降低 ,以非拔牙侧更显著 ,随着缺牙时间的延长这些变化而更显著。结论 :异常负荷可导致软骨细胞蛋白多糖合成的减少及其构成的变化 ,从而使髁突纤维软骨的粘弹性降低。
砄bjective:To examine the expression of proteoglycans (PGs) in mandibular condyle cartilage following abnormal loading. Methods:The animal model of abnormal loading on mandibular condyle was established by extracting the left lower molars in adult rabbits. Temporomandibular joints of two sides were surgically obtained 2 weeks, 1 month and 3 months after tooth extraction respectively, and embedded in paraffin. Sections in 5 μm thick were prepared and processed for alcian blue and tublin blue staining.Results:2 to 3 months after loss of teeth, the expression of sulfated glycosaminoglycon (GAG) and PGs decreased in both condyles,and that decreased more in the condyles on non extraction side. Conclusion:The synthesis of PG in chondrocyte in mandibular condyle may be affected by abnormal stress.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2001年第2期112-114,共3页
Journal of Practical Stomatology
