摘要
在豚鼠心室肌标本上,利用固定频率起搏技术,研究了3,6-(二甲氨基)-二苯骈碘杂六环依地酸盐(IHC-72)对豚鼠右心室乳头状肌生理特性的影响,IHC-72对豚鼠心室肌呈剂量依赖性负性变力作用,其IC_(50)为0.21±s0.07mmol·L^(-1);延长功能不应期,降低肾上腺素诱发的自律性,对兴奋性则无明显影响,IHC-72对频率依赖性正阶梯现象和静息后增强效应也呈抑制作用,实验结果提示,IHC-72不但抑制心肌细胞钙的跨膜转运,它还影响细胞内储钙的释放。
In this paper, we studied the effects of 3, 6-dimethylamino-dibenzopyriodonium edetate (IHC-72) on physiological characteristic of isolated guinea pig papillary muscles. IHC-72 significantly and dose-dependently decreased the contractility of guinea pig papillary muscles, prolonged the functional refractory period (FRP) from 171± 14 to 229± 13 s ((x|-)±s, P<0.01) and decreased the automaticity induced by epinephrine (P<0.01), but it exerted no influence on the excitability. IHC-72 101.6 μmol·L-1 could also inhibit the frequency-dependent positive staircase phenomenon and the post-rest potentiation (PRP).The experimental results suggest that the effects of IHC-72 on physiological characteristic of guinea pig papillary muscles may be not only related to the inhibition of Ca2+ influx across sarcolemma, but also related to that of the intracelluar Ca2+ release.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1992年第4期268-271,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
IHC-72
心肌
3, 6-dimethylamino-dibenzo-pyriodonium edetate contractility automaticity functional refractory period papillary muscles calcium
