摘要
目的 探讨正己烷毒性的作用机制。方法 采用静式染毒方式连续 8h给 SD大鼠吸入正己烷 15 g/ m3。结果 大鼠全血 GSH含量明显降低 ,t- test P<0 .0 1;大鼠血清中 MDA含量虽有增多的趋势 ,但无统计学意义 (t- test P>0 .0 5 ;大鼠肝组织中 SOD和 GSH- Px活性明显降低 ,t- test P<0 .0 1。结论 正己烷可引起或增强机体氧自由基反应 ,导致脂质过氧化损伤 ,这可能是烷烃类物质对机体毒性作用机制之一。
Objective To study the mechanism of toxicity of hexane Methods SD rats inhaled 15 g/m3 n hexane statically for 8 hours Results The levels of GSH in whole blood of rats declined significantly (t test,P<0 01) The levels of MDA in serum of rats revealed increasing trend but without statistical significance (t test,P?/40 05) The activities of SOD and GSH Px in liver of rats decreased significantly (t test,P<0 01). Conclusion n Hexane could induce or enhance the reaction of oxygen free radical in organism,and result in damages of lipid peroxidation,which might be one of the mechanisms of the toxicity of alkane
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2001年第2期86-88,共3页
Journal of Environment and Health
