摘要
作者回顾性研究了我室50年收集的410例病理学上诊断为小儿肝脂肪变性病例,其中37例根据美国疾病控制中心的诊断标准诊断为Reye综合征(RS)。对RS作了组织学和超微结构的病理学研究,显示主要病理变化为:弥漫性微泡性肝脂肪变性(泡沫状肝细胞)和肝细胞线粒体损伤。讨论了RS的病理诊断及鉴別诊断,线粒体损伤在发病中的作用和病毒感染、水杨酸制剂的应用与发病关系。
37 cases of Reye's syndrome, collected in 50 years period, were studied retrospectively by light microscopy and electron microscopy (EM). The main histopathologioal findings included: The diffuse microvesicular steatoSiS of the liver and cerebral edema without perivasoular or meningeal inflammation. Microvesicular fatty change was also observed in heart and kidney. By means of EM, liver-cell mitochondria were greatly swollen and pleomorphio, and intramitochondrial dense bodies were reduced or absent. The lesion in the liver or any other organs responsible for mitochondria injures. The differential diagnosis and pathogenesis of Reye's syndrome were discussed. The etiology of the syndrome and its relationship to the viral disease which usually precedes it were reemphasized.
出处
《上海医科大学学报》
CSCD
1992年第6期434-437,共4页
Journal of Fudan University(Medical Science)
关键词
REYE综合征
泡沫状肝细胞
脑病
Baye's syndrome
foamy liver cell
acute noninflammatory ence-phalopathy
