摘要
用多普勒超声心动图和随机双盲法对比了卡托普利(C)和吲哒帕胺(Ⅰ)治疗50例高血压病患者5月前后的LA、IVST、PWT、LVDd、LVMI、IRT、Ei、Ai及Ai/Ei。结果两组病人血压均显著降低,IRT显著缩短。C组IVST、PWT和LVMI显著减少(P均<0.001),Ei显著增高,Ai/Ei和LA显著降低;Ⅰ组则不然。提示C能使高血压病人左室的肥厚显著消退,并显著改善左室舒张功能。
Fifty patients with mild to moderate essential hypertension were randomly assigned to either Captopril (C group, n=25) or Indapamide (I group, w=25) treatment in a double-blind protocal for 5 momths (M5), M-mode 2-D and pulsed Doppler echocardio-grams were performed at baseline and the end of trial measaring left atrial(LA) diameter, diastolic septal thickness (1VST) and posterior wall thickness (FWT). LV end-diasto-lic diameter (LVDd), isovolumic relaxation time(IRT), A and E velocity-lime imegral(A1, E1). The LV mass index(LVMI) and the ratio of Ai and Ei(Ai/Ei) were calculated.In I group only 21 cases completed the study. At M5 the BP levels have a significant reduction both groups (P<0.01). In C group, Doppler echocardiography showed a signifi-can, reduction of IVST from 12.9±2.6 to 11.5±2.9mm(P<0.001), PWT from 9.9±1.7 to 8.8±1.5mm(P<0.001), LVMI from 148±34 to 127±37g/m2 (P<0.001), LA from 37.3±4.5 to 36.1±5.0mm (P<0.05), IRT from 0.104±0.014 to 0.093±0.016s(P<0.01) and Ai/Ei from 0.96±0.56 to 0.69±0.34 (P<0.05). The Ei was significanty increased from 0.096 ±0.03 to 0.117 to 0.03m((P<0.001). In I group, only IRT was significantly reduced from 0.104±0.006 to 0.098±0.011s(P<0.01)Theother parameters showed no significant change in both groups.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1993年第1期6-9,共4页
Journal of Clinical Cardiology
