摘要
目的 :探讨中潜伏期听觉电反应 (MLR)在早期诊断糖尿病中枢神经病变 (DCN)中的作用 方法 :应用链脲佐菌素 (STZ)腹腔注射法 ,建立实验性糖尿病 (ED)动物模型 并在成模前后按时间顺序动态观测MLR的变化 结果 :建模后 4周实验性糖尿病 (ED)组出现MLRP0 、Na、Pa、Nb、Pb波峰潜伏期 (PL)延长 (P <0 .0 5) 6周后出现MLR各波PL、Pa-Pb 波峰间潜伏期 (IPL)延长 (P <0 0 1) 8周后MLR各波PL、P0 -Pa、Pa-PbIPL均延长 (P <0 .0 5或P <0 .0 1) ED组血糖与MLR的PL、IPL变化之间无相关 ,ED组病程与MLRNa、Nb、Pb 波PL变化有正相关 结论 :糖尿病早期MLR出现PL和IPL延长 ,该变化与病程进展有相关关系 。
Aim:To study the changes of auditory middle latency response (MLR) in diabetic rats and to investigate the role of MLR in the early diagnosis of diabetic central neuropathy (DCN).Methods:Experimental diabetes (ED) rat model was used. Before and after 2,4,6,8 and 10 weeks of ED modeling, MLR was measured. Results:The peak latency (PL) of P 0、N a、P a、N b、P b of MLR of ED group prolonged after 4w of ED modeling ( P <0 05). All PL and P a-P b interpeak latency (IPL) of MLR prolonged after 6w( P <0.01). All the PL、P 0-P a\,P a-P b IPL of MLR prolonged after 8w( P <0.05, P <0 01). There was positive correlation between the duration of diabetes and N a\,N b\,P b PL of MLR. Conclusion:The PL and IPL of MLR prolonged in early ED. MLR was sensitive and valuable in the early diagnosis of DCN.[
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
2001年第1期129-132,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
