摘要
１５８例重型颅脑损伤患者，在常规治疗基础上加用高压氧（ＨＢＯ）和脑活素治疗５４例，治愈率６３．０％，总有效率９４．４％；与常规治疗组、单加ＨＢＯ组及单加脑活素组相比，疗效明显提高，病死率明显降低，后遗症明显减轻，经统计学处理有显著差异（Ｐ＜０．０１或Ｐ＜０．０５）。作者讨论了重型颅脑损伤的病理机理及ＨＢＯ和脑活素的作用机理，认为ＨＢＯ与脑活素均能改善颅脑损伤后脑缺氧，两者合用有叠加作用。
58
cases of severe head injury were reported.Of which, 54 cases were treated by hyperbaric
oxy-gen(HBO)and cerebrolysin on the basis of routine clinical treatment, the cure rate was
63.0% and the overall effective rate was 94.4%,In this treatment the effectiveness was much
higher,the fatality much lower and subsequent sequelae were fewer or less severe as
compared with those of the routine treatment group and the groups treated with HBO or
cerebrolysin alone on the basis of routine treat-ment(P< 0.01 or P <0.05 ).The pathophysiologic
mechanism of severe head injury and the action mechanisms of HBO and cerebrolvsin were
discussed.It was considered that HBO and cerebrolvsin both can alleviate anoxia of brain after
injury,and the combination of them have additive effect.
关键词
高压氧
脑活素
缺氧
颅脑损伤
Brain injury Hyperbaric
oxygen Cerebrolysin Anoxia
