摘要
目的确定长沙地区引起急性胃肠炎诺如病毒的类型。方法从128例腹泻患者粪便中,提取RNA。将RNA进行逆转录、扩增、测序,并通过构建基因进化树进行分析导致长沙地区患者感染的诺如病毒的主要种类。结果63个样品中含有诺如病毒,分别为GII-3、GII-4、GII-12三种类型,其中GII-4为主要病原体。结论在长沙地区,诺如病毒GII-4是引起病毒性胃肠炎的的主要致病株。GII-4基因进化快速,已成为全球范围内导致急性胃肠炎的最常见病毒株。
Objective To determine the dominant Norovirus genotypes and strains associated with of acute gastroenteritis in Changsha. Methods Fecal samples were obtained from 116 patients affected with acute gastroenteritis in Changsha from March 2012 to November 2012. Norovirus RNA was amplified, sequenced, and phylogenetically analyzed to determine the dominant genotypes and strains. Results Norovirus were detected in 63 samples, including GII - 3 ,GII - 4, GII - 12, and GII - 4 being the dominant genotype. Conclusions The predominant genotype of norovirus infections in Changsha is GII - 4. Norovirus GII -4, which are evolving rapidly, are responsible for gastroenteritis epidemics worldwide.
出处
《社区医学杂志》
2014年第12期12-13,共2页
Journal Of Community Medicine
