摘要
病理性近视是引起亚洲人群视力损害的常见原因之一,它的发生与遗传因素高度相关.目前,已发现多个病理性近视的候选基因位点,包括胶原类基因、基膜类基因、生长因子类基因、转录因子类基因等,它们作用于巩膜、角膜、视网膜等不同部位从而影响眼生长发育并引起病理性近视.
Pathological myopia is one of the most frequent causes of visual impairment in Asian population and is now deemed to be highly relevant to genetic factors.In recent years,a number of genetic loci for pathological myopia have been identified,including genes for collagen,lumican,growth factors,transcriptional factors,and so on.These genetic loci may affect the development of the eye and cause pathological myopia by acting on different structures,such as sclera,cornea and retina.
出处
《国际眼科纵览》
2014年第3期194-198,共5页
International Review of Ophthalmology
基金
北京市自然科学基金（7112031）
国家自然科学基金（81272981）
北京市卫生系统高层次卫生科技人才培养计划（2009-3-32）
关键词
病理性近视
遗传学
基因
pathological myopia
genetics
gene
