摘要
目的综合评价p53基因第72位密码子多态性与食管癌发病易感性的关系。方法从PUBMED、中国知网（CNKI）和万方学位论文数据库中检索研究p53基因第72位密码子多态性与食管癌易感性关系的公开发表论文,使用STATA 11.0软件分析p53基因第72位密码子与食管癌易感性的关系。使用比值比（Odds Ratio,OR）和95%可信区间（95%Confidence Interval,95%CI）作为效应指标。同时,评价所纳入研究的异质性及发表偏倚。结果共有9篇p53第72位密码子多态性与食管癌易感性相关的公开发表论文被纳入本研究,共包括病例3032例,对照3924例。分析结果显示,p53基因第72位密码子的Pro等位基因相对于Arg的合并OR值为1.34,95%CI为1.17～1.53;显性模式和隐性模式下合并OR值及95%CI分别为1.30（1.13～1.50）和1.27（1.10～1.45）;纯合基因型Pro/Pro相对于Arg/Arg的合并OR值及95%CI为1.67（1.27～2.18）,P均〈0.01。结论 p53第72位密码子的Pro等位基因是食管癌的易感因素,Pro/Pro纯合基因型使食管癌的患病风险明显增加。
Objective To investigate the association between p53 Arg72Pro polymorphism and esophageal cancer （EC） risk using meta- analysis. Methods All eligible studies published before December, 2012 were selected by searching Pub - Med and CNKI using keywords ＂p53＂ or ＂TP53＂, ＂polymorphism＂, ＂esophageal ＂ ,＂cancer＂ and ＂meta - analysis＂. Odds ratio（OR） and 95% confidence interval （95% CI） were used to evaluate the strength of association between p53 codon72 polymorphism and risk of esophageal cancer development. At the same time, heterogeneity between included studies and publication bias were also evaluated. Results Total 9 case - control studies with 3032 cases of esophageal cancer and 3924 controls were enrolled into this study. The meta -analysis showed that the combined odds ratio （OR） for Pro allele was 1,34 （95 % CI： 1.17 - 1.53 ） times higher than Arg allele; the ORs of recessive model and homozygote comparison were 1.30（95% CI： 1.13 ～ 1.50） and 1.82 （95% CI： 1.28 ～2.59） separately; the OR for Pro/Pro and Arg/Arg was 1.67 （95 % CI： 1.27 ～ 2.18 ） ; all P values were less than 0.05. Conclusion The p53 codon72 Pro allele plays an important role in susceptibility to esophageal cancer development. And the Pro/Pro genotype may increase the esophageal cancer risk in the Chinese population.
出处
《宁夏医科大学学报》
2014年第1期6-9,共4页
Journal of Ningxia Medical University
基金
国家自然科学基金(81160249)
宁夏自然科学基金重点项目(13057)
2012宁夏留学回国人员创新创业项目
