摘要
目的 对 1972～ 2 0 0 0年 10月间 2 30 0例次肾移植情况进行临床分析。方法 统计肾移植后受者 1、3、5年的人、肾存活率 ;肾移植主要并发症及其处理原则 ;影响受者再次移植存活率的因素 ;HLA 抗原 /基因配型及群体反应抗体 (PRA)检测情况。结果 ( 1)自 1985年使用环孢素A(CsA)后 1年人、肾存活率 (人、肾均存活 )为 87.33 % ,3年为 80 .17% ,5年为 6 7.0 4%。 ( 2 ) 5 0岁以上肾移植患者 35 3例 ,1年移植肾存活率 83.44 % ( 2 5 2 / 30 2 ) ,1年人存活率 85 .43 % ( 2 5 8/ 30 2 )。 ( 3)肾移植术后患者心脑血管系统疾病占死亡原因的 5 0 .7% ,感染占死亡率的 13 .5 %。 ( 4)恶性肿瘤的发病率为 1.46 % ( 2 3/ 15 80 )。 ( 5 )良好的HLA供 受者配型可减少术后急性排斥反应的发生率 ,利于移植肾的长期存活。结论 良好的组织配型 ,肾移植术后免疫抑制药物的合理应用 ,对移植术后并发症的预防和及时治疗是提高肾移植术后人
Objective To analyze the clinical data of 2 300 renal transplantations from 1972 to Oct. 2000. Methods The graft survival rate at 1, 3, 5 year, main complications of renal transplantation and treatment, the factors contributive to the mortality and the factors affecting the re transplant grafts’ survival rate were observed. HLA antigen gene typing and population response antibody (PRA) was detected.Results The graft survival rates at 1, 3, 5 years were 87.33 ?%, 80.17 ?% and 67.04 ?% respectively after administration of CsA since 1985. In the 353 recipients aged over 50 years, one year graft survival rate was 83.44 ?% and 1 year patient survival rate 85.43 ?%. Cardiocerebral vascular diseases were the main diseases, accounting for 50.7 ?% of the factors of death after renal transplantation, infection for 13.5 ?%. The incidence of the malignancy was 1.46 ?% (25/ 1 580 ). The incidence of acute rejection was 27?%, 35.5?% , 22.4 ?%, 20.85 ?%, 0, 0 respectively when the HLA mismatches were 6, 5, 4, 3, 2 and 1. Conclusion Good HLA match, rational use of immunosuppressants after renal transplantation, the prevention of post transplantation complications and immediate treatment were the main factors improving long term graft/patient survival rate.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2001年第2期78-81,共4页
Chinese Journal of Organ Transplantation
关键词
肾移植
存活率
并发症
临床分析
Renal transplantation
Survival rate
Complication
