摘要
【目的】探索一种新的体外反搏实验装置和实验方法。【方法】自行设计制作一套适合比格犬清醒状态下长期接受反搏治疗的装置 ,该装置由反搏主机、反搏架、反搏内外囊套等组成。采用导管端式压力传感器检测主动脉根部压力 ,评价该系统的即时血流动力学效果。 6条比格犬接受了即时血流动力学测定和长期体外反搏治疗 ,治疗总时间约 2 8～ 30h不等(每日 1次 ,每次 1～ 2h) ,历时 6～ 8周。【结果】反搏中实验犬的主动脉舒张期增压波可达 ( 174 0± 18 4)mmHg ,显著高于反搏前的舒张压 (P <0 0 1)。舒张压与收缩压比值 ( pD/ pS)上升至 1 2 4± 0 0 5。此外 ,反搏过程中 ,主动脉收缩压平均下降达 ( 19 2 2± 8 70 )mmHg。全部动物能顺利完成慢性体外反搏治疗观察 ,且动物的食欲、精神状态等无异常改变。【结论】该装置应用于体外反搏的慢性动物实验研究是可行的。
Objective To develop a new divice and approach for enhanced external counterpulsation (EECP) in awaking dogs. Methods The device was designed specially for dogs which consisted of main console, support frame, external and inner balloon cuffs. The hemodynamic effects of the new EECP device were examined in six beagle dogs by direct measurement of aortic pressure. The total EECP time was 28 to 30 hours (1～2 hours daily for each dog). Results The aortic diastolic pressure(p D) was highly enhanced when augmentation pressure increased to (174 0±18 4) mmHg (P<0 01) while aortic systolic pressure (p S) decreased by (19 22±8 70) mmHg with p D/p S ratio of 1 24±0 05 during EECP. These dogs didn′t develop any changes in appeptite and mental state during the long term EECP experiment. Conclusion The new device of EECP can achieve good hemodynamic effects and the EECP protocol conducted in this study is reliable and feasible for further study of EECP in awaking dogs.
出处
《中山医科大学学报》
CSCD
北大核心
2001年第2期93-96,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
国家"九.五攻关"基金资助项目! (96 -90 6 -0 2 -12 )
中美辅助循环研究基金资助项目 !(0 40 )
关键词
慢性体外反搏
反搏动术
犬
实验装置
实验方法
counterpulsation/methods
counterpulsation/instruments and equipment
dog
