摘要
目的探讨男性乳腺神经内分泌癌的临床病理及免疫组化特征。方法分析2例男性乳腺神经内分泌癌临床特点,观察其组织病理形态及免疫表型,并结合文献进行复习。结果年龄56岁、60岁,临床表现为乳腺肿块。肿瘤细胞圆形、卵圆形或梭形,中等大小,排列成梁状、巢片状,梭形细胞排列成栅栏状、流水状,偶见菊形团结构。免疫组化染色结果:Syn、CgA、NSE、34BE12、CK5/6、E-Cadherin弥漫(+);例1 CD57弥漫(+);例2 CD56弥漫(+)、ER、PR(++),GCDFP-15、PS2部分(+)。结论男性乳腺神经内分泌癌临床罕见,易发于老年人,依据肿瘤细胞形态特点,结合免疫表型可确诊。
Objective To investigate the clinical pathology and immunohistochemical features of male neuroen- docrine breast cancer. Methods The histopathologieal features and immune phenotype were observed in two eases of male neuroendocrine breast cancer, and the related literature was reviewed. Results Age：56 and 60-year-old, the clinical manifestations ： breast lumps. Tumor cells round, oval or spindle-shaped, medium size, arranged with trabeeu- lar or nest Flake, spindle-shaped cells arranged in the fence or with water, chrysanthemum-shaped structure of corpo- rations were occasionally observed. Immune phenotype：Syn, CgA, NSE,34BE12, CK5, E-Cadherin diffusedly（ ＋ ） ; diffusedly CD57 （ ＋ ） in example 1 ; CD56 diffusedly（ ＋ ） ,ER and PR（ ＋＋ ） ,GCDFP-15 and PS2 Some（ ＋ ） in example 2. Conclusion Male breast neuroendocrine cancer is rare and could be observed basing on morphological characteristics and immune phenotype.
出处
《肿瘤基础与临床》
2014年第3期237-239,共3页
journal of basic and clinical oncology
关键词
乳腺肿瘤
神经内分泌癌
免疫表型
男性
breast tumor
neuroendocrine cancer
immune phenotype
male
