摘要
目的：观察穴位埋线疗法对慢传输型便秘（STC）患者临床疗效及其对结肠传输功能、血浆P物质（SP）、血管活性肠肽（VIP）的影响。方法收集2012年3月至2013年1月青岛市黄岛中医院、青岛市海慈医疗集团、青岛大学医学院附属医院的STC患者128例，采用随机数表法将患者随机分为两组各64例。治疗组采用穴位埋线治疗，对照组口服乳果糖口服液治疗，疗程均为4周。观察两组患者治疗前后的临床疗效及对结肠传输功能、SP、VIP 的影响。结果治疗组治疗前便秘评分量表（CCS）评分为（13.52±3.93）分、治疗后为（8.15±3.77）分；对照组治疗前为（14.11±4.24）分、治疗后为（9.01±2.93）分，两组治疗后 CCS 评分均较同组治疗前降低（P＜0.01），但组间比较差异无统计学意义（P＞0.05）。治疗后两组血浆SP、VIP水平[治疗组分别为（46.73±1.50）ng/L、（206.10±12.14）ng/L，对照组分别为（40.92±6.25）ng/L、（214.73±7.62）ng/L]均较同组治疗前[治疗组分别为（26.66±0.88）ng/L、（332.68±17.84）ng/L，对照组分别为（23.32±1.75）ng/L、（306.22±20.01）ng/L]改善，差异有统计学意义（P＜0.05），且两组比较，血浆SP、VIP水平差异均有统计学意义（P＜0.05）。结论穴位埋线疗法可改善STC患者的临床症状及结肠传输功能，并可能通过调节血SP、VIP水平达到治疗效果。
Objective To explore the clinical efficacy of acupuncture point embedding therapy in the treatment of slow transit constipation （STC）and the influence on the colon transmission function,plasma substance P（SP）, vasoactive intestinal peptide（VIP）. Methods A total of 128 slow transit constipation patients were involved in the study and divided randomly into two groups by using stochastic indicator： a treatment group （treated with acupuncture point embedding therapy） and a control group （treated with lactulose oral liquid）. The clinical effects, colon transmission function, the influence of SP, and VIP were observed for STC patients. Results In the treatment group, CCS score was （13.52±3.93） before treatment and（8.15±3.77） after the treatment. In the control group CCS score was （14.11±4.24） and （9.01±2.93） respectively before and after the treatment, CCS score in both groups showed significantly improvement after the treatment （P〈0.01）, and there was no significant difference between groups （P〉0.05）. The plasma SP and VIP level of the two groups after the treatment [treatment group （46.73±1.50） ng/L,（206.10±12.14） ng/L, the control group（40.92±6.25）ng/L,（214.73± 7.62）ng/L] were also improved than before [treatment group was（26.66±0.88）ng/L, （332.68±17.84）ng/L, the control group was （23.32±1.75）ng/L,（306.22±20.01）ng/L], with statistically significant（P〈0.05）, and the difference between the two groups were also significant（P〈0.05）.Conclusion The acupuncture point embedding therapy is effective for STC, and it can regulate the level of SP and VIP.
出处
《国际中医中药杂志》
2014年第7期617-619,共3页
International Journal of Traditional Chinese Medicine
