摘要
目的：观察复方血栓通胶囊治疗早期糖尿病肾病的临床疗效。方法收集2011年9月至2012年10月河南省商丘市第一人民医院内分泌科90例早期糖尿病肾病住院患者，按病例尾号将患者随机分为两组各45例。对照组予以糖尿病教育、控制血糖、控制血压、调节血脂等治疗；治疗组在对照组治疗基础上加用复方血栓通胶囊，3粒/次，3次/d。治疗12周后，比较两组治疗前后血糖、糖化血红蛋白、尿微量白蛋白、尿微量/肌酐比值的变化。结果①两组尿微量白蛋白、尿白蛋白/肌酐比较：两组治疗后尿微量白蛋白、尿微量肌酐比值[治疗组分别为（24.5±9.1）mg/L、（2.39±1.6）mg/mmol，对照组分别为（85.9±8.6）mg/L、（5.6±2.1）mg/mmol]均较同组治疗前[治疗组为（142.5±20.8）mg/L、（27.1±5.3）mg/mmol，对照组为（141.6±21.6）mg/L、（26.3±5.6）mg/mmol]明显降低（P＜0.01或0.05），且治疗组疗效优于对照组（P＜0.05）。②两组FBG、2 hBG、HbA1c水平比较：治疗后两组FBG、2 hBG、HbA1c水平[治疗组分别为（5.58±1.57）mmol/L、（7.82±2.43）mmol/L、（7.01±1.22）%，对照组分别为（5.67±1.46）mmol/L、（7.71±2.59）mmol/L、（6.83±2.31）%]均较同组治疗前[治疗组分别为（8.69±1.59）mmol/L、（12.79±2.50）mmol/L、（9.91±1.98）%，对照组分别为（8.72±1.56）mmol/L、（12.86±2.25）mmol/L、（9.89±2.03）%]下降（P＜0.05），但组间比较差异无统计学意义（P＞0.05）。结论复方血栓通胶囊可有效治疗早期糖尿病肾病，阻止肾损害。
Objective To observe the clinical effect of early diabetic nephropathy treated with Fufang-Xueshuantong capsule. Methods 90 hospitalized patients from September 2011 to October 2012 with early diabetic nephropathy were recruited in Shangqiu First people＇s hospital endocrinology of Henan Province. All patients were divided into two groups randomly, with 45 patients in each group. The control group was treated with diabetes education, blood glucose control, blood pressure control, and blood lipid regulation, while the treatment group was treated with Fufang-Xueshantong capsule on the basis of the control group. The change of blood glucose, HbA1c, urine microalbumin, and Ualb/Cr were measured before and 12 weeks after the treatment. Results ① Compared the urine microalbumin, Ualb/Cr of the two groups before and after treatment：the urine microalbumin, Ualb/Cr of the two groups after the treatment [Treatment group was（24.5±9.1）mg/L,（2.4± 1.6）mg/mmol, Control group was（85.9±8.6）mg/L,（5.6±2.1）mg/mmol] were significantly reduced than before the treatment （P〈0.01 or 0.05）[Treatment group was （142.5±20.8）mg/L, （27.1±5.3）mg/mmol, Control group was （141.6±21.6）mg/L, （26.3±5.64）mg/mmol], while the effect of treatment group was better than control group（P〈0.05）. ② Compared the FBG, 2 hBG, HbA1c of the two groups before and after treatment：After treatment the level of FBG, 2 hBG, HbA1c of the two groups [Treatment group was（5.58±1.57）mmol/L,（7.82±2.43）mmol/L, （7.01± 1.22）%, Control group was（5.67 ± 1.46）mmol/L,（7.71 ± 2.59）mmol/L,（6.83 ± 2.31）%]were also reduced than before（P〈0.05）. [Treatment group was （8.69±1.59）mmol/L,（12.79±2.50）mmol/L,（9.91±1.98）%, Control group was（8.72±1.56）mmol/L, （12.86±2.25）mmol/L,（9.89±2.03）%], but there was no statistically difference between the groups（P＆gt;0.05）. Conclusion Fufang-Xueshuantong capsule had good effect in treating early diabetic nephropathy, it can also delay the progress of renal damage.
出处
《国际中医中药杂志》
2014年第7期610-612,共3页
International Journal of Traditional Chinese Medicine
关键词
复方血栓通胶囊
糖尿病肾病
疗效分析
Fufang-Xueshuantong capsule
Diabetic nephropathy
Therapeutic effect analysis
