摘要
目的：观察疏肝健脾方联合胡椒敷脐治疗腹泻型肠易激综合征（irritable bowel syndrome with diarrhea，IBS-D）伴精神心理障碍的临床疗效。方法收集2011年1月至2013年1月年广州市南沙中心医院就诊的IBS-D伴精神心理障碍患者64例，按随机数字表法随机分为2组，治疗组33例，予疏肝健脾法方药口服配合胡椒敷脐治疗；对照组31例，予匹维溴铵和氟哌噻吨美利曲辛治疗，疗程4周。观察疗效，对比治疗前后抑郁积分（HAMD）、焦虑积分（HAMA）、生活质量积分（IBS-QOL）和症状严重程度积分（IBS-SSS）。结果治疗后，治疗组和对照组HAMD积分、HAMA积分、IBS-SSS积分较同组治疗前下降（治疗组t值分别为14.280、13.530、18.847，对照组t值分别为11.514、9.424、13.829， P＜0.01），IBS-QOL积分较同组治疗前升高（t分别为-16.848、-11.712，P＜0.01）。治疗后治疗组HAMA积分、IBS-SSS积分、IBS-QOL积分改善优于对照组（t分别为-3.183、-2.549、3.904，P＜0.01或0.05）。治疗组总有效率为94%（31/33）、对照组为75%（23/31），两组总有效率比较，差异有统计学意义（χ^2＝4.727， P＜0.05）。结论疏肝健脾方配合胡椒敷脐可有效改善IBS-D伴精神心理障碍患者的临床症状、抑郁焦虑状态，提高生活质量。
Objective To observe the traditional Chinese medicine （TCM） and umbilical treatment on diarrhea-predominant irritable bowel syndrome（IBS-D）with mental disorders. Methods Thirty-seven cases with IBS-D were randomized into a treatment group（33 cases） and a control group（31 cases）. The treatment group was given Shugan-Jianpi TCM decoction and pepper umbilical dressing. The control group was given Pinaverium Bromide Tablets and Flupentixol and Melitracen tablets. After having been treated for 4 weeks, Hamilton Anxiety Scale（HAMA）, Hamilton Depression Scale（HAMD）, IBS Symptom Severity Scale（IBS-SSS）, IBS quality of life questionnaire （IBS-QOL） were determined. Results After the treatment, HAMD, HAMA, IBS-SSS in the treatment group and the control group all significantly decreased （the treatment group t=14.280, 13.530, 18.847,the control group t=11.514, 9.424, 13.829, P〈0.01）, and IBS-QOL increased markedly（t=-16.848, -11.712, P〈0.01）. Compared with HAMA, IBS-SSS and IBS-QOL in treatment group, the control group showed statistical difference（t=-3.183, -2.549, 3.904, P〈0.01 or 0.05）. The total effective rate of the treatment group was 94%higher than 75%of the control group（χ^2=4.727, P〈0.05）. Conclusion Shugan-Jianpi TCM decoction and pepper umbilical dressing can improve the clinical symptoms and psychological symptoms and improve the quality of life of IBS-D patients.
出处
《国际中医中药杂志》
2014年第7期604-606,共3页
International Journal of Traditional Chinese Medicine
关键词
疏肝健脾
敷脐
精神心理障碍
腹泻型肠易激综合征
Traditional Chinese medicine
Umbilical treatment
Irritable bowel syndrome with diarrhea
Mental disorders
