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Notch信号通路与生殖干细胞研究进展 被引量：5

Research Progress on Notch Signaling Pathway and Germline Stem Cells
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摘要 Notch信号通路是一个在进化中高度保守的信号通道,具有调控细胞增殖、分化及凋亡的作用。近年来,随着研究的不断深入,发现Notch信号通路与生殖干细胞的增殖分化及干细胞微环境的作用机理密切关联,Notch信号通路在生殖系统发育及疾病治疗中的作用机制逐渐引起人们的广泛关注。该文综合论述了Notch信号通路的生理特性及功能,重点阐述Notch信号通路在精原干细胞、卵巢生殖干细胞及生殖干细胞微环境系统中的调控机制。 As a high evolutionarily conserved system during evolution, Notch signaling pathway participates in regulation of cellular differentiation, proliferation and death. In recent years, researches have shown that the element of Notch signaling pathway is complex, which is primarily related to proliferation and differentiation of germline stem cells and the role of stem cell niche. It also plays an extremely important role in reproductive system development and disease treatment. In this study, we summarized the physiological characteristics and functions of Notch signaling pathway, and focused on the role of regulating onfemale germline stem cells, male germline stem cells and germline stem cell niche.
作者 李佳 孙梦黎 黄健 潘小玲 郑月慧
机构地区 南昌大学医学院医学实验教学部 南昌大学期刊社
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2014年第6期841-846,共6页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:81160081 81360100)资助的课题~~
关键词 NOTCH信号通路 生殖干细胞 干细胞微环境 增殖 分化 Notch signaling germline stem cells stem cell niche proliferation differentiation
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学] Q257 [生物学—细胞生物学]
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参考文献49

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二级参考文献180

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共引文献37

同被引文献78

  • 1朱小明,蔡婕,黄荷凤.卵巢低反应的诊断标准和预测[J].中国实用妇科与产科杂志,2006,22(5):388-390. 被引量：51
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引证文献5

二级引证文献5

中国细胞生物学学报
2014年 第6期

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