摘要
目的 探讨新型袢利尿剂托拉塞米注射液治疗儿童肾病综合征高度水肿的临床疗效.方法 对本科室2010年1月至2013年12月收治的肾病综合征患儿进行临床分析,将32例肾病综合征高度水肿患儿按随机数字表法分为托拉塞米组和呋塞米组,每组16例.两组在口服泼尼松足量[2 mg/（kg·d）或60 mg/（m^2·d）]治疗的基础上,托拉塞米组静脉滴注托拉塞米1～2 mg/（kg·d）,呋塞米组静脉滴注呋塞米1～2 mg/（kg·d）,疗程为5d.两组患儿分别于治疗前、治疗后第2、4、6d检测24 h尿量、体重、血液生化各项指标的变化情况,并记录不良反应.结果 托拉塞米与呋塞米两组患儿临床疗效比较,尿量均较治疗前明显增加,水肿消退,体重减轻,两组总有效率之间差异有统计学意义（94％ vs.81％; x2=3.023,P＜0.05）.呋塞米组患儿血钾浓度明显低于托拉塞米组（P＜0.05）,血尿酸明显高于托拉塞米组（P＜0.05）.结论 托拉塞米治疗儿童肾病综合征顽固性水肿,疗效显著,副作用小,对电解质及肾功能无明显影响,值得临床应用.
Objective To study the clinical effects of torasemide in the treatment of nephrotic syndrome with intractable edema （referred to the infant nephropathy）.Methods Clinical analysis was carried out to infants with kidney disease admitted in our department from January 2010 to December 2013,32 cases of infant kidney disease were divided into Torasemide group and Furosemide group,on the basis of the two oral prednisone sufficient quantities [2 mg/（kg · d） or 60 mg/（m^2 · d）].Torasemide group,16 patients,were given intravenous infusion of torasemide 1-2 mg/（kg · d）,Furosemide group with 16 cases were given intravenous infusion of furosemide 1-2 mg/（kg · d） for 5 days.The patients of two groups were detected for 24 h urine,electrolyte changes,and we recorded the adverse reactions before and after treatment of 2,4,6 days.Changes in the amount of urine,serum potassium and trioxypurine as the primary efficacy endpoint.Results Among the children of two groups with clinical use of torasemide and furosemide,urine output increased significantly as compared with that before treatment,showing edema fading,weight lose.Total efficiency in two groups was statistically significantly different （94% vs 81%）.Serum potassium concentration in Furosemide group was significantly lower than that of Torasemide group （P 〈 0.05）,trioxypurine concentration in Furosemide group was significantly higher than that of Torasemide group （P 〈 0.05）.Conclusion The torasemide in the treatment of nephrotic syndrome with intractable edema has significant clinical curative effect,with less side-effect,without obvious effect to electrolyte and renal function,which is worthy of clinical promotion.
出处
《国际医药卫生导报》
2014年第13期1951-1954,共4页
International Medicine and Health Guidance News
关键词
肾病综合征
水肿
托拉塞米
呋塞米
疗效
Nephrotic syndrome
Edema
Torasemide
Furosemide
Curative effect
