摘要
目的:观察他克莫司软膏联合地塞米松治疗面部脂溢性皮炎的临床效果及不良反应。方法:90例面部脂溢性皮炎患者随机分为2组,对照组(n=45例)仅采用他克莫司软膏治疗,观察组(n=45例)采用他克莫司软膏联合地塞米松治疗,两组疗程均为4周。观察两组疗效、治疗前后皮损程度及不良反应。结果:观察组治疗总有效率(95.6%)明显高于对照组(82.2%)(P<0.05);两组治疗前红斑、鳞屑、瘙痒及皮损总评分比较无显著差异性(P>0.05),治疗后两组(红斑、鳞屑、瘙痒及皮损)评分均显著性下降,且观察组的各种症状评分下降幅度较对照组更为显著(P<0.05);观察组不良反应发生率(8.9%)明显低于对照组(22.2%)(P<0.05)。结论:他克莫司软膏联合地塞米松治疗面部脂溢性皮炎疗效显著,不良反应少,值得临床推广应用。
Objective：To observe the efficacy of Tacrolimus ointment combined with dexamethasone on treatment of facial seborrheic dermatitis and its adverse reactions.Methods：90 cases of facial seborrheic dermatitis were randomly divided into two groups, tacrolimus ointment was used on the control group （n=45 patients） for 4 weeks while tacrolimus ointment combined with betamethasone were treated on the observation group （n=45 patients） for 4 weeks. The effects, lesion extent and adverse reactions were observed before and after treatment in both groups.Results：The total effective rate （95.6%） of the observation group was significantly higher than that of the control group （82.2%） （P〈0.05）;the erythema, scaling, itching and skin lesions total score of the two groups before treatment showed no significant difference （P〉0.05 ）, After treatment, the scores of both groups significantly decreased, and the scores of observation group decreased more significantly than that of the control group （P〈0.05）; the incidence of adverse reactions in （8.9%） observation group was significantly lower than that of the control group （22.2%） （P〈0.05 ）.Conclusion：The effects of tacrolimus ointment combined with dexamethasone on treatment of facial seborrheic dermatitis was notable with a few adverse reactions and worthy of clinical application.
出处
《中国医药导刊》
2014年第5期865-866,共2页
Chinese Journal of Medicinal Guide
关键词
他克莫司软膏
地塞米松
脂溢性皮炎
Tacrolimus ointment
Dexamethasone
Seborrheic dermatitis
