摘要
目的：对比羟基喜树碱和丝裂霉素膀胱灌注化疗对膀胱癌术后复发临床效果。方法：回顾性分析我院2006年4月至2011年2月收治的70例接受膀胱癌经尿道膀胱肿瘤电切术治疗的患者的临床资料。结果：两组患者均得到（2-3）年的随访，手术之后3个月和半年，两组患者的肿瘤复发率之间不具有统计学差异（P〉0.05）；但是手术之后1年和2年，羟基喜树碱组患者的肿瘤复发率明显比丝裂霉素组低，二者相比具有统计学差异（P〈0.05）；羟基喜树碱组和丝裂霉素组患者的不良反应发生率分别为22.86%和62.86%，羟基喜树碱组患者的不良反应发生率明显比丝裂霉素组患者低，二者相比具有统计学差异（P〈0.05）。结论：羟基喜树碱较丝裂霉素膀胱灌注化疗对膀胱癌术后复发具有较好的临床效果。
Objective：To compare the effect of hydroxycamptothecin and mitomycin intravesical chemotherapy on the clinical effect of postoperative recurrence of bladder cancer.Methods：The clinical data of 70 cases of patients with bladder cancer by transurethral resection of bladder tumor treatment in our hospital from 2006 April to 2011 of February were retrospectively analyzed.Results：Two patients were 2-3 years of follow-up after operation, 3 months and a half, with no significant difference between two groups of patients with tumor recurrence rate （P〉0.05）;but the operation after 1 years and 2 years, tumor recurrence hydroxycamptothecin groups were significantly lower than mitomycin group, two were compared with statistical the difference （P〈0.05）; adverse reaction of hydroxy camptothecin group and MMC group were respectively 22.86%and 62.86%, the adverse reaction of hydroxy camptothecin group patients were significantly better than mitomycin group were low, two compared with statistical difference（P〈0.05）.Conclusion：Mitomycin intravesical chemotherapy hydroxycamptothecin has good clinical effect of postoperative recurrence of bladder cancer.
出处
《中国医药导刊》
2014年第5期853-853,855,共2页
Chinese Journal of Medicinal Guide
关键词
羟基喜树碱
丝裂霉素
膀胱灌注化疗
膀胱癌术后复发
临床效果
Hydroxy camptothecin
Mitomycin
Bladder perfusion chemotherapy
Postoperative recurrence of bladder cancer
Clinical effect
