摘要
目的:探讨超敏C反应蛋白在青春期多囊卵巢综合征肥胖患者血清中的表达水平以及其临床意义。方法:67例青春期多囊卵巢综合征患者,其中33例BMI≥25 kg/m2,为肥胖观察组;34例BMI<25 kg/m2,为非肥胖观察组。另选23例正常少女,设为对照组。采用生化方法检测血清中hs-CRP、血糖、血脂、性激素、胰岛素等的水平,对比各组情况并做相关性分析。结果:肥胖观察组患者的hs-CRP表达水平明显较非肥胖观察组和对照组高,P<0.05。Spearman相关性分析结果示,hs-CRP表达水平同BMI、腰臀比、三酰甘油以及睾酮的表达水平呈正相关,P<0.05;同胰岛素敏感指数和抵抗指数无相关性,P>0.05。结论:PCOS肥胖病人机体内或有低强度慢性炎症存在,C反应蛋白水平能够反应肥胖以及高雄激素血症的轻重程度。
Objective：To investigate the expression levels of high-sensitivity C-reactive protein in the serum of adolescents with polycystic ovary syndrome and its clinical significance.Methods：67 cases of adolescents with polycystic ovary syndrome, in which 33 cases（ BMI≥25 kg/m2）were allocated to the obese observation group, 34 cases （BMI〈25 kg/m2） were allocated to the non-obese observation group, and the other selected 23 cases of normal girl were allocated to the control group. Biochemical methods was used to detect serum hs-CRP, blood sugar, blood lipids, hormones and insulin level.Results：hs-CRP levels of obese observation group were significantly higher than non-obese observation group and control group, P〈0.05.Spearman correlations revealed significant positive correlations of hs-CRP with BMI, waist hip ratio（WHR）, testosterone and TG（P〈0.05）in all teenagers. The hs-CRP was found to have no correlations with HOMA-IR and ISI（P〉0.05）.Conclusion：The study demonstrates that obese teenagers with polycystic ovary syndrome may be in a low-grade inflammation status, C-reactive protein levels can reflect the severity of obesity and hyperandrogenism.
出处
《中国医药导刊》
2014年第5期755-756,758,共3页
Chinese Journal of Medicinal Guide
关键词
C反应蛋白
多囊卵巢综合征
青春期
肥胖
C-reactive protein
Polycystic ovary syndrome
Adolescent：Pbesity
