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微小RNA-7在上皮性卵巢癌原发灶及转移灶中表达的研究 被引量：4

The expression of miR-7 in primary epithelial ovarian cancer tissues and metastatic tissues
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摘要 目的:检测上皮性卵巢癌组织原发灶、转移灶中miR-7及其靶标EGFR蛋白的表达,探讨miR-7及EGFR与卵巢癌转移的关系。方法:采用显色原位杂交(CISH)检测miR-7在卵巢癌组织原发灶、转移灶石蜡切片中的表达;采用免疫组化检测EGFR蛋白表达。结果:上皮性卵巢癌转移灶中miR-7表达显著低于原发灶(P<0.05),而EGFR表达显著高于原发灶(P<0.05);miR-7与EGFR表达具有相关性(r=-0.441,P<0.05)。结论:miR-7可能通过EGFR抑制卵巢癌的转移,miR-7可能成为治疗卵巢癌的新靶标。 Objective：To detect the expressions of miR-7 and EGFR in metastatic or primary EOC tissues and analyze the relationship between miRNA-7 or EGFR and the metastatic epithelial ovarian carcinoma. Methods： The expression of miR-7 in metastatic or primary EOC tissues was determined by CISH. IHC was used to evaluate the expression of EGFR. Results：The expression of miR-7 in primary EOC tissues was higher than that in metastatic EOC tissues（ P〈0.05 ）. The expression of EGFR in primary EOC tissues was lower than that in metastatic EOC tissues（P〈0.05 ）. The expressions of miR-7 and EGFR had correlation（ r=-0. 441, P〈0.05 ）. Conclusion： MiR-7 may inhibit ovarian cancer metastasis through EGFR, and miR-7 might be a potential therapeutic target.
作者 楼微华 周星辰 邱丽华
机构地区 上海交通大学医学院附属仁济医院妇产科上海市教委重点学科上海市妇科肿瘤重点实验室
出处 《现代妇产科进展》 CSCD 2014年第5期341-343,共3页 Progress in Obstetrics and Gynecology
基金 国家自然基金委面上项目(No:81072138) 上海交通大学医工交叉项目(No:YG2010MS24) 上海交通大学医学院附属仁济医院重点学科项目
关键词 上皮性卵巢癌 表皮生长因子受体 微小RNA-7 转移 Epithelial ovarian cancer EGFR miR-7 Metastasis
分类号 R737.33 [医药卫生—肿瘤]
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参考文献13

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现代妇产科进展
2014年 第5期

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