摘要
目的:探讨糖尿病(DM)患者日常饮食中抗氧化营养素和体内氧化应激水平对其血糖控制的影响,为临床合理饮食指导提供依据。方法:收集本院内分泌科住院DM患者49例,根据国内判断DM患者血糖控制与否的糖化血红蛋白(HbA1c)标准,将患者分为血糖控制良好组(G组)和控制不佳组(P组),调查其膳食中抗氧化营养素锌(Zn)、硒(Se)、维生素(Vit)A、VitC和VitE摄入量,检测患者血清HbA1c、抗氧化微营养素及氧化应激标志物8-异前列腺素F2α(8-iso-PGF2α)。比较2组患者膳食抗氧化营养素摄入量,及其与血清抗氧化营养素水平、氧化应激水平和血糖控制间的关系。结果:所有患者中仅G组有1例患者5种膳食抗氧化营养素摄入量全部达到参考摄入量,其余患者均存在不同程度的摄入不足。其中抗氧化营养素摄入不足种类≥3种者达34例(69%)。P组每日VitC摄入量未达参考摄入量的患者比例显著高于G组(86%比57%,P=0.025),2型DM(T2DM)显著高于1型DM患者(83%比58%,P=0.049)。P组患者血清8-iso-PGF2α水平显著高于G组(P=0.034),T2DM患者中P组亦高于G组(P=0.028)。所有49例患者的血清8-iso-PGF2α与HbA1c水平呈显著正相关(r=0.386,P=0.006),在T2DM患者中亦呈正相关(r=0.446,P=0.013)。结论:多数DM患者的膳食抗氧化营养素摄入不足,更多见于血糖控制不佳者和T2DM患者。
Objective To investigate the effect of antioxidant nutrients intake and oxidative stress level on glycemiccontrol in diabetic patients, and to provide evidence for clinical dietary intervention. Methods Dietary recall was used toestimate the dietary intake of antioxidant nutrients such as zinc, selenium, vitamin A, C and E in 49 in-hospital diabeticpatients. Patients were divided into two groups based on glycated hemoglobin （HbAic） criteria good glycemic control group（G group）, and poor glycemic control group （P group）. Serum HbAlo, levels of antioxidant nutrients, and oxidative stressmarker 8-iso-prostaglandin F2α （8-iso-PGF2α） were measured. Level of dietary intake of antioxidant nutrients, level of serumantioxidant nutrients and oxidative stress level between the two groups were compared. Results Only 1 patient in G grouphad dietary intake of all five kinds of antioxidant nutrients met the reference intake, and the remaining patients hadvarying degrees of insufficient antioxidant nutrients intake. Insufficient intake of ≥ 3 kinds of antioxidant nutrients wasseen in 34 patients （69%）. The proportion of patients with vitamin C daily intake below the reference level in P group wassignificantly higher than that in G group （86% vs 57%, P=0.025）; the proportion in type 2 diabetes （T2DM） wassignificantly higher than in type 1 diabetes （83% vs 58%, P=0.049）. The average serum 8-iso-PGF2α level in P group wassignificantly higher than that of G group （P=0.034）, T2DM in P group was also significantly higher （P=0.028）. In all 49patients, serum 8-iso-PGF2α was positively correlated with HbAlc level （r=0.386, P=0.006 ）, this was also seen in T2DMpatients （r=0.446, P=0.013）. Conclusions Most diabetic patients had insufficient dietary intake of antioxidant nutrients,especially in patients with poor glycemic control and in T2DM patients.
出处
《内科理论与实践》
2014年第2期152-156,共5页
Journal of Internal Medicine Concepts & Practice
关键词
糖尿病
膳食调查
抗氧化营养素
氧化应激
血糖控制
Diabetes mellitus
Dietary survey
Antioxidant nutrients
Oxidative stress
Glycemic control
